Anjali Soni

The preformulation studies involves description, solubility, melting point, of the drug were found to be comparable with the standard. Based on the all above preformulation studies the drug was suitable for making the transdermal formulation. Based on all these factors the transdermal drug delivery system F5 was having greater % drug release. The formulation F5 shows better extended release up to 24hrs when compared to other formulations. So it was concluded that the formulation F5 prepared by using Eudragit RS100 and HPMC is the better formulation for control release of drug up to 24hrs of time. However, the best formulation F-5 follows first order kinetics and the mechanism of diffusion. Results of the present study encouraged that it can be used as controlled drug delivery system and frequency of administration can be minimized.

In the present research work, an attempt has been made to optimize and formulate bilayer tablet of saxagliptin and repaglinide to achieve immediate release of saxagliptin and sustained release of repaglinide. Saxagliptin is DPP-4 inhibitor and belonging to BCS class 1 (high solubility, high permeability). It has long half life, so an attempt was made to achieve its fast action by making immediate release tablet by using superdisintegrant sodium starch glycolate.. Repaglinide is an oral blood glucose-lowering drug of the maglitinide class used in the management of type 2 diabetes mellitus. It is absorbed by oral route and has short half life, so an attempt has been done to make sustained release tablet of repaglinide And it was concluded that the optimized formula RG4 (75 mg) drug (98.6 %) in 12 hrs. So by taking both optimized formulation in fixed dose combination in different layer. A bilayer tablet was prepared with 50 mg saxagliptin and 500 mg of repaglinide.

Bilayer tablet has been made and evaluated. For various precompression and post compression parameter. Precompression parameter shows that the granules and blends of repaglinide and saxagliptin have good Carr's index and hausner's ratio indicate that both granules and blends were free flowing. The angle of repose shows that granules and blends have excellent flow and post compression parameter show that bilayer tablet have thickness hardness and weight and friability within the I. P. limit and bilayer tablet have swelling index 82% in 6 hrs and have drug release first layer of saxagliptin release 98.6% in 30 minutes and second layer repaglinide release 95.5% in 12 hrs.