Avneet Kaur

Poor water solubility of active pharmaceutical ingredients (APIs) presents a significant challenge in oral drug administration, leading to reduced bioavailability and compromised therapeutic effectiveness. This study aimed to address this issue by developing an optimized itraconazole nanosuspension for intranasal delivery, potentially enhancing drug availability across the blood-brain barrier. Then a nanosuspension was prepared and characterized using various analytical techniques. FTIR and DSC analyses verified the drug's chemical structure and crystalline state . A Box-Behnken Design was employed to optimize the formulation, resulting in nanoparticles with favorable size, polydispersity index, zeta potential, and entrapment efficiency. TEM imaging revealed a core-shell structure of the nanoparticles. The optimized nanosuspension demonstrated improved drug release compared to a conventional suspension. These findings suggest that the developed itraconazole nanosuspension has potential to enhance the drug's solubility and bioavailability.

Lymphatic filariasis, considered globally as a neglected tropical disease (NTD), is a parasitic disease caused by microscopic, thread-like worms, the parasite damages the lymph system. Most of the infected people have no symptoms and will never develop clinical symptoms. Fixed dose combination kits have emerged as a potential technique for the treatment of lymphatic filariasis. LF is treated with a mix of pharmacological therapy, vector control, and preventative measures. FDC kits for the treatment of LF are made up of two or more antifilarial medicines that target distinct phases of the parasite's life cycle. These kits make treatment regimens easier to follow, increase patient compliance, and improve overall treatment results. The use of FDC kits in LF therapy has various advantages. It removes the need for patients to take various pills or capsules at different times, decreasing therapy complexity and boosting adherence. Antifilarial medicine combination and dose standardisation decreases the possibility of incorrect drug selection or dosage mistakes. Furthermore, the combination of various medications in FDC kits may aid in the prevention of drug resistance.

Imaginez le monde sans couleur. Tout, m me ce qui est disgracieux, peut tre rendu esth tiquement plaisant par l'utilisation de la couleur. Lorsqu'elle est utilis e correctement, la couleur tablit l'ordre, d finit l'espace et l' quilibre, transmet l' motion et cr e l'atmosph re. Il faut avoir ce que l'on appelle le "sens des couleurs", c'est- -dire la capacit de s lectionner la couleur appropri e, pour pouvoir les voir toutes. Une couleur peut communiquer. Il est essentiel d'apprendre le langage des couleurs pour les comprendre. Bien qu'elle soit g n ralement mal communiqu e, elle est souvent prononc e. Il est imp ratif de comprendre la science et l'art de la couleur afin de surmonter avec succ s les difficult s pos es par la s lection des teintes en dentisterie restauratrice cosm tique. En cons quence, la couleur joue un r le important dans le complexe esth tique de la dentisterie et aide consid rablement d limiter les comportements esth tiques et non esth tiques. Afin de surmonter les difficult s li es la s lection des teintes en dentisterie esth tique, il est essentiel d'apprendre l'art et la mani re de s lectionner les teintes dans la dentisterie esth tique. Il est essentiel d'apprendre l'art et la science de la couleur. Une troite collaboration entre le clinicien et le technicien de laboratoire est galement n cessaire. Ce n'est qu' cette condition que l'on peut obtenir une restauration esth tique.