Bapu Thorat

A rea o de Mitsunobu muito importante para a s ntese de ter a partir de fenol e lcool. O 7-metoxi-2-(4-metoxifenil)-1-benzofurano-5-il]metanol (2) foi sintetizado a partir da vanilina utilizando uma s rie de rea es conhecidas, tais como a rea o de Mannich, acetila o, hidr lise, rea o de Wittig e hidrogena o. Este derivado de metanol benzofurano (2) condensou com 4-fluorofenol utilizando DEAD em THF. O produto final 5- (4-fluorofenoxi)metil]-7-metoxi-2-(4-metoxifenil)-1-benzofurano (3) foi caracterizado utilizando IR, NMR e espectros de massa e estudou-se a sua atividade biol gica atrav s de acoplamento molecular utilizando o software de acoplamento molecular Glide. A atividade do ter (3) foi comparada com a do seu an logo amina.

Reakcja Mitsunobu jest bardzo ważną reakcją w syntezie eteru z fenolu i alkoholu. 7-metoksy-2-(4-metoksyfenylo)-1-benzofuran-5-ylo]metanol (2) zostal zsyntetyzowany z waniliny przy użyciu serii znanych reakcji, takich jak reakcja Mannicha, acetylacja, hydroliza, reakcja Wittiga, uwodornienie. Ta pochodna benzo-furanu metanolu (2) skondensowala się z 4-fluorofenolem przy użyciu DEAD w THF. Ostateczny produkt 5- (4-fluorofenoksy)metylo]-7-metoksy-2-(4-metoksyfenylo)-1-benzofuran (3) scharakteryzowano za pomocą IR, NMR i widm masowych, a jego aktywnośc biologiczną zbadano za pomocą dokowania molekularnego przy użyciu oprogramowania Glide. Aktywnośc eteru (3) por wnano z jego analogiem aminowym.

La reazione di Mitsunobu molto importante per la sintesi dell'etere dal fenolo e dall'alcol. Il 7-metossi-2-(4-metossifenil)-1-benzofuran-5-il]metanolo (2) stato sintetizzato dalla vanillina utilizzando una serie di reazioni note quali la reazione di Mannich, l'acetilazione, l'idrolisi, la reazione di Wittig e l'idrogenazione. Questo derivato del metanolo benzofurano (2) stato condensato con 4-fluorofenolo utilizzando DEAD in THF. Il prodotto finale 5- (4-fluorofenossil)metil]-7-metossi-2-(4-metossifenil)-1-benzofurano (3) stato caratterizzato mediante IR, NMR e spettri di massa e ne stata studiata l'attivit biologica mediante docking molecolare utilizzando il software di docking molecolare Glide. L'attivit dell'etere (3) stata confrontata con quella del suo analogo amminico.

Heteroatoms constitute a very common fragment of a number of active pharmaceutical ingredients as well as excipients; from the point of view of significance, it is all the same if these are isosterically/bioisosterically replaced carbons/carbon substructures in aliphatic structures or real heterocycles. Many heterocyclic scaffolds can be considered as privilege structures including aromatic skeletons. Most frequently, nitrogen heterocycles or various positional combinations of nitrogen atoms, sulphur, and oxygen in five- or six-membered rings/fused rings can be found. There are a number of novel pathways found for their synthesis including homogenous or heterogenous catalytic system. According to statistics, more than 85% of all biologically-active chemical entities contain a heterocycle. This fact reflects the central role of heterocycles in modern drug design therefore their synthesis is important.

The world is facing the problem of tuberculosis. In accounts for approximately one third of the global incidence of TB (Goble Tuberculosis Report, 2018, World Health Organization). Each year, 1.8 million new cases (the global incidence is 6.4 million), which lead to 1.3 million deaths (range, 1.2-1.4 million) among HIV-negative people, and there were an additional 300 000 deaths from TB (range, 266 000-335 000) among HIV-positive people, although the prevalence of HIV among new cases in India is just 3-4 percent compared with global average of 9 percent. Although the existing method of curing is very effective against TB, the length of treatment, the toxicity and the potential for drug-drug interactions are factors that highlight the need for new anti-TB drugs. New drugs are urgently needed because TB remains a global health priority, as around nine million new cases are estimated each year with almost two million fatalities. The libraries of different substituted synthetic and natural molecules were scanned against this cell wall proteins, DNA, enzymes by using different computational programs, studying their SAR properties and other molecular structural based properties.