Dharmendra Solanki

The book on drug delivery system aims to serve as a complete textbook for the students of M. Pharm I semester keeping in mind specific requirements of the Pharmacy Council of India (PCI), Education Regulation - 2020. This textbook is covering the entire syllabus of pharmaceutics I semester as per new PCI norms recognized as MPH102T. It contains seven units. It gives a comprehensive Study and regulation of rate-controlled administration of therapeutic agents. It sustains the Equilibrium between the basic essentials and Advanced area of knowledge, it serves as a backbone of pharmaceutics. Exposure to the students with respect to drug delivery systems becomes important in University imparting higher education. This Textbook describes the theories, applications, and challenges for different controlled release/Sustained formulations. This book differs from most in its focus on controlled release formulation design and process development. It also covers the drug delivery areas like rate controlling drug delivery systems, Gastro-retentive drug delivery systems, Occular drug delivery systems, Transdermal drug delivery systems, Protein and peptide delivery, and vaccine deliver.

Podręcznik na temat systemu dostarczania lek w ma slużyc jako kompletny podręcznik dla student w I semestru M. Pharm, mając na uwadze szczeg lne wymagania Rady Farmacji Indii (PCI), Rozporządzenie w sprawie edukacji - 2020. Niniejszy podręcznik obejmuje caly program nauczania farmacji I semestru zgodnie z nowymi normami PCI uznanymi za MPH102T. Ten podręcznik zawiera siedem jednostek. Zapewnia kompleksowe badanie i regulację kontrolowanego tempa podawania środk w terapeutycznych. Utrzymuje r wnowagę między podstawowymi podstawami a zaawansowanym obszarem wiedzy, sluży jako kręgoslup farmacji. Ekspozycja na student w w odniesieniu do system w dostarczania lek w staje się ważna na uniwersytecie zapewniającym wyższe wyksztalcenie. Niniejszy podręcznik opisuje teorie, zastosowania i wyzwania związane z r żnymi preparatami o kontrolowanym uwalnianiu. Książka ta r żni się od większości tym, że koncentruje się na projektowaniu preparat w o kontrolowanym uwalnianiu i opracowywaniu proces w. Obejmuje r wnież obszary dostarczania lek w, takie jak systemy dostarczania lek w kontrolujące szybkośc, systemy dostarczania lek w zatrzymujących się w żolądku, okulistyczne systemy dostarczania lek w, przezsk rne systemy dostarczania lek w, dostarczanie bialek i peptyd w oraz dostarczanie szczepionek.

The preformulation studies involves description, solubility, melting point, of the drug were found to be comparable with the standard. Based on the all above preformulation studies the drug was suitable for making the transdermal formulation. Based on all these factors the transdermal drug delivery system F5 was having greater % drug release. The formulation F5 shows better extended release up to 24hrs when compared to other formulations. So it was concluded that the formulation F5 prepared by using Eudragit RS100 and HPMC is the better formulation for control release of drug up to 24hrs of time. However, the best formulation F-5 follows first order kinetics and the mechanism of diffusion. Results of the present study encouraged that it can be used as controlled drug delivery system and frequency of administration can be minimized.

In the present research work, an attempt has been made to optimize and formulate bilayer tablet of saxagliptin and repaglinide to achieve immediate release of saxagliptin and sustained release of repaglinide. Saxagliptin is DPP-4 inhibitor and belonging to BCS class 1 (high solubility, high permeability). It has long half life, so an attempt was made to achieve its fast action by making immediate release tablet by using superdisintegrant sodium starch glycolate.. Repaglinide is an oral blood glucose-lowering drug of the maglitinide class used in the management of type 2 diabetes mellitus. It is absorbed by oral route and has short half life, so an attempt has been done to make sustained release tablet of repaglinide And it was concluded that the optimized formula RG4 (75 mg) drug (98.6 %) in 12 hrs. So by taking both optimized formulation in fixed dose combination in different layer. A bilayer tablet was prepared with 50 mg saxagliptin and 500 mg of repaglinide.

Bilayer tablet has been made and evaluated. For various precompression and post compression parameter. Precompression parameter shows that the granules and blends of repaglinide and saxagliptin have good Carr's index and hausner's ratio indicate that both granules and blends were free flowing. The angle of repose shows that granules and blends have excellent flow and post compression parameter show that bilayer tablet have thickness hardness and weight and friability within the I. P. limit and bilayer tablet have swelling index 82% in 6 hrs and have drug release first layer of saxagliptin release 98.6% in 30 minutes and second layer repaglinide release 95.5% in 12 hrs.