Dinesh Kumar Sharma

The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.

The aim of the present study is to formulate & evaluate a suitable matrix type transdermal polymeric film of Olmesartan Medoxomil using two different polymeric combinations, Eudragit RL 100 (E RL 100) and Hydroxyl Propyl Methyl Cellulose (HPMC). The preformulation parameters were evaluated for their suitability to formulate transdermal polymeric film. The transdermal polymeric film was successfully prepared and critically investigated. The evaluation parameter such as FTIR for its compatibility of the drug with polymer, Scanning Electron Microscopy (SEM) photographs of the prepared film were taken to see the drug distribution pattern, Physical studies including moisture content, moisture uptake, flatness to study the stability of the formulations and In vitro permeation study is conducted in a modified Franz's diffusion cell by using rat skin membrane & cellophane membrane. The obtained result confirms that it complies as per specification or reported methods. Based on the above observations, it can be reasonably concluded that E RL 100 & HPMC polymers are the best-suited polymers for the development of TDDS of Olmesartan Medoxomil.

The book comprises nineteen chapters that focus on the production technologies of horticultural crops, including: 1) Horticulture, 2) Orchard Designing & Planting Systems, 3) Orchard Floor Management, 4) Description of Fruit Crops, 5) Description of Vegetable Crops, 6) Nursery Raising Techniques in Fruit Crops, 7) Nursery Raising Techniques in Vegetable Crops, 8) Propagation Techniques for Horticulture Crops, 9) Canopy Management Techniques, 10) Leaf and Soil Sampling Techniques, 11) Integrated Nutrient Management (INM) in Vegetable Crops, 12) Field Preparation, Layout of Experimental Plot, and Calculation of Fertilizer Doses for Vegetable Crops, 13) Exotic Vegetables, 14) Hydroponics in Vegetable Cultivation, 15) Weed Management in Horticultural Crops, 16) Cultural Practices for Medicinal Plants, 17) Annuals and Their Management, 18) Flower Arrangements, and 19) Architectural Landscaping.

The book provides a comprehensive overview of production technologies for horticulture crops, encompassing a total of 19 chapters. These chapters cover a range of topics, including: orchard design and planting systems, orchard floor management, descriptions of fruit and vegetable crops, nursery raising techniques for fruit and vegetable crops, propagation techniques for horticulture crops, canopy management techniques, leaf and soil sampling techniques, integrated nutrient management in vegetable crops, field preparation, layout of experimental plots, and calculation of fertilizer doses for vegetable crops, exotic vegetables, hydroponics in vegetable cultivation, weed management in horticultural crops, cultural practices for medicinal plants, annuals and their management, flower arrangements, and architectural landscaping.