Durga Prasad Beda

Die "sublinguale Verabreichung von Medikamenten" beinhaltet traditionell die systemische Verabreichung ber die Schleimhaut des Mundbodens oder die ventrale Oberfl che der Zunge. Die sublinguale Schleimhaut ist aufgrund der lipoiden Beschaffenheit der Schleimhaut mit einer reichen Vaskulatur relativ durchl ssig, was eine schnelle Absorption erm glicht und eine akzeptable Bioverf gbarkeit aufweist. Es ist bequem, erleichtert die einfache Verabreichung und seine F higkeit, den hepatischen First-Pass zu umgehen. Diese Forschung erarbeitet ber die Entwicklung Sublingual" Tabletten von ISBD NT(Isosorbiddinitrat). Im Vergleich zu allen "Formulierungen zeigte ISDN4 eine hohe" prozentuale "Wirkstofffreisetzung, d.h. 97,15 % "in 8 min, so dass es als beste Formulierung angesehen wird, die Pullulan als Super-Desintegrat in der Konzentration von 10 mg enth lt".

La consegna sublinguale di farmaci tradizionalmente" comporta la somministrazione sistemica attraverso la membrana mucosa del pavimento della bocca o la superficie ventrale della lingua. La mucosa sublinguale relativamente permeabile a causa della natura lipoidale della membrana mucosa con una ricca vascolarizzazione, che permette un rapido assorbimento e ha una biodisponibilit accettabile. conveniente, facilita la facilit di somministrazione e la sua capacit di bypassare il primo passaggio epatico. Questa ricerca elaborare circa lo sviluppo Sublingual" compresse di ISBD NT (Isosorbide dinitrato). Rispetto a tutte le "formulazioni ISDN4 ha mostrato un alto" % "rilascio della droga cio , 97,15 % "in 8 min quindi considerato come migliore formulazione che contiene Pullulan come super disintegrato nella concentrazione di 10 mg".

L'administration sublinguale de m dicaments implique traditionnellement une administration syst mique par la muqueuse du plancher buccal ou la surface ventrale de la langue. La muqueuse sublinguale est relativement perm able en raison de la nature lipo dique de la muqueuse et de sa riche vascularisation, ce qui permet une absorption rapide et une biodisponibilit acceptable. Elle est pratique, facilite l'administration et sa capacit contourner le premier passage h patique. Cette recherche porte sur le d veloppement de comprim s sublinguaux de dinitrate d'isosorbide NT (ISBD). Compar toutes les formulations, ISDN4 a montr un pourcentage lev de lib ration du m dicament, c'est- -dire 97,15 % en 8 minutes, et est donc consid r comme la meilleure formulation qui contient du Pullulan sous forme de super-d sint gr la concentration de 10 mg.

A "administra o de drogas sublinguais tradicionalmente" envolve a administra o sist mica atrav s da membrana mucosa do assoalho da boca ou da superf cie ventral da l ngua. A mucosa sublingual relativamente perme vel devido natureza lipoidal da membrana mucosa com uma rica vasculatura, que permite uma r pida absor o e tem uma biodisponibilidade aceit vel. conveniente, facilita a facilidade de administra o e a sua capacidade de contornar a primeira passagem hep tica. Esta pesquisa elabora sobre o desenvolvimento de comprimidos "sublingual" de ISBD NT(dinitrato de isossorbida). Comparado a todas as "formula es ISDN4 mostrou alta" % de "libera o de drogas, ou seja, 97,15% "em 8 minutos, portanto considerado como a melhor formula o que cont m Pullulan como super desintegrador na concentra o de 10 mg".

Podjęzykowe podawanie lek w tradycyjnie" polega na podawaniu og lnoustrojowym przez blonę śluzową dna jamy ustnej lub brzuszną powierzchnię języka. Blona śluzowa podjęzykowa jest stosunkowo przepuszczalna ze względu na lipoidalną naturę blony śluzowej z bogatym unaczynieniem, co umożliwia szybkie wchlanianie i ma akceptowalną biodostępnośc. Jest to wygodne, ulatwia latwośc podawania i jego zdolnośc do ominięcia wątroby pierwszego przejścia. Niniejsze badania dotyczą opracowania "podjęzykowych" tabletek ISBD NT (dinitrat izosorbidu). W por wnaniu do wszystkich "preparat w ISDN4 wykazal wysoki" % "uwalniania leku, tj. 97,15 % "w ciągu 8 minut, więc jest uważany za najlepszy preparat, kt ry zawiera Pullulan jako super disintegrate w stężeniu 10 mg".

Sublingual drug delivery traditionally" involves systemic administration via mucosal membrane of floor of mouth or the ventral surface of tongue. The sublingual mucosa is relatively permeable due to the lipoidal nature of mucous membrane with a rich vasculature, which allows rapid absorption and has acceptable bioavailability. It is convenient, facilitates ease of administration and its ability to bypass hepatic first pass. This research elaborate about development Sublingual" tablets of ISBD NT(Isosorbide dinitrate). Compared to all "formulations ISDN4 showed high" % "drug release i.e., 97.15 % "in 8 min so it is considered as best formulation which contains Pullulan as super disintegrate in the concentration of 10 mg".

Since the last decade, the paradigm has been shifted to "Green Chemistry" to meet the challenges of sustainable development. It has become the quest and challenge for chemists to develop green reaction process without affecting their efficiency to reduce the environmental impact. Further, it is likely that the green chemistry trend will continue to grow over the next few decades. Interestingly, the Biginelli-scaffolds have shown promising value in drug development as they exhibit a wide spectrum of pharmacological activities. During the past years, copious research has been done on Biginelli-scaffolds and several reaction conditions were reported to ease the classical Biginelli-reaction. This book provides insights on green method for the synthesis of Biginelli-scaffolds by both microwave and conventional methods using sulfamicacid as a potential catalyst and further synthesis of 4-aryl-3,4-dihyropyrimidin-2(3H)-onesand biological screening for various pharmacological activities.