Gurpreet Kaur

In 1892, Sir William Osler noted, "If it were not for the great variability among individuals medicine might as well be a science and not an art". This statement now a century old still embodies the influence of genetic variability on treatment outcomes both in Medicine and in Periodontics. Although, periodontitis does not follow Mendelian inheritance patterns, evidence is mounting of important hereditary influences. In fact, in developed countries, the strongest risk predictor of many common illness including diabetes, heart diseases and cancer is family history. Knowledge of hereditary influence of disease is not a new finding and it seems likely that oral cavity is excluded from genetic factors. An important problem related to research in the hereditary of periodontitis is that, whatever the cause of the disease, the symptoms are the same: deepening of periodontal pocket, loss of attachment and bone loss. The more susceptibility factors an individual has inherited, the greater the genetic predisposition and higher the chance for early development of periodontitis.

Nikoo älskar att måla. En dag läser han en äventyrsberättelse om det stora blå havet och tar som vanligt fram sin pensel. Plötsligt faller han in i sin egen målning! Akvarellillustrationer sveper oss in i Nikoos fantasivärld.

Chitosan is the deacetylated form of chitin. Generally, the substance becomes soluble in dilute acids when the degree of deacetylation is more than 50%. The solubility of chitosan in dilute acids is often needed to be modified when specific drug release properties have to be tailored into the dosage form. The available toxicological data on chitosan and its modified forms appears to indicate its safety for oral use because high doses have been found to be tolerated well in rodents and rabbits. However, its local action as a haemostatic together with its ability to activate macrophages and cause cytokine release may require a careful assessment of its safety for parenteral use. This book offers the dynamics of chitosan's detailed composition.