Harry Harris

During the last few years the science of human genetics has been expanding almost explosively. Original papers dealing with different aspects of the subject are appearing at an increasingly rapid rate in a very wide range of journals, and it becomes more and more difficult for the geneticist and virtually impossible for the non geneticist to keep track of the develop­ ments. Furthermore, new observations and discoveries relevant to an overall understanding of the subject result from investigations using very diverse techniques and methodologies and originating in a variety of different disciplines. Thus, investigations in such various fields as enzymology, immunology, protein chemistry, cytology, pediatrics, neurology, internal medicine, anthropology, and mathematical and statistical genetics, to name but a few, have each contributed results and ideas of general significance to the study of human genetics. Not surprisingly it is often difficult for workers in one branch of the subject to assess and assimilate findings made in another. This can be a serious limiting factor on the rate of progress. Thus, there appears to be a real need for critical review articles which summarize the positions reached in different areas, and it is hoped that "Advances in Human Genetics" will help to meet this requirement. Each of the contributors has been asked to write an account of the position that has been reached in the investigations of a specific topic in one of the branches of human genetics.

The Fab Five who won a century of England caps epitomised their ages! Billy Wright sprinkled glamour on to a nation desperate to throw off post-war austerity. He married a Beverley Sister, the Spice Girls of his generation, and played at Wolverhampton Wanderers, where they made the first great experiment in European football, under floodlights. Bobby Moore represented the cool of the sixties. As happy mixing with movie stars as the general public, Moore was a man of the people, an East End lad made good. The image of him walking from the players exit at Upton Park and tossing a set of keys to a group of boys to unlock his Jaguar sums up his approach to life. Long after he had retired, Bobby Charlton was the single English name most recognised abroad and remains the top scorer for his country. He is still regarded as the finest player ever to pull on an England shirt and was pivotal to Alf Ramsey's plans for success in '66. Peter Shilton kept goal in two of English footballs pivotal moments, the defeat by Poland in 1973 and the World Cup semi-final with West Germany 17 years later. He summed up a generation of footballers who liked a pint and a bet but who would give everything for a shirt with Three Lions on it. He is regarded as perhaps England's greatest 'keeper. David Beckham represents the present celebrity age, completing the circle from the Billy Wright era. But it emphasised how the game had changed. Footballers never earned big money in Wrights era thanks to the maximum wage, whereas the multi millions put Beckham into a financial class of his own. The Fab Five could soon to be expanded to eight as Ashley Cole Steven Gerrard and Frank Lampard approach their respective tons. Harry Harris tells the tale of each of the England centurions and with it the era he played in from the 1950s and England's emergence from post-war gloom, through the glory of '66 to the present day trials and tribulations of a national team seemingly never far from controversy.

After one billion pounds, eight managers in eight years, that 'ghost' goal defeat at Anfield in 2005, a penalty shoot-out defeat in the Moscow final against Manchester United, in 2008 and a scandalous refereeing performance against Barcelona in the semi-final a year later, owner Roman Abramovich got his hands on the trophy he craved in Munich. After eight years in charge, Abramovich's dream of owning the best team in Europe has finally been realised. As Didier Drogba was handed the trophy for the first time at the presentation in Munich, he handed it straight to the guy at the end looking as though he had gate-crashed the party. But this was no ordinary fan on the periphery. This was the guy whose billions helped create the Champions League winners. Legendary football columnist Harry Harris follows Chelsea's remarkable progress through the 2011-12 tournament and the incredible finish that saw them dispose of the 2011 winners Barcelona and Bayern Munich on their own grounds.

This is the inside story of Manchester City's first title in 44 years and perhaps the most remarkable football season of all-time written from the point of view of the man in the eye of the storm - City manager Roberto Mancini. A season that ended so dramatically, with two injury-time goals at the Etihad to secure the club's first Premier League title, had begun serenely for the Sky Blues as they romped to the top of the league scoring goals almost at will, culminating in a 6-1 romp at Old Trafford. Holding the lead at the top from September until March, their title juggernaut was halted by Manchester United's incredible run of performances and the loss of form of key players. It took a remarkable collapse from United to hand back the initiative, a second chance Mancini's men gratefully accepted with a run of six wins to secure the title - yet there was so much more to this incredible season. Controversy was never far away: Carlos Tevez on-off transfer, his shocking refusal to come off the bench in Munich and his subsequent 'strike' became an unwanted distraction. Yet his return just in time to add much needed impetus to City's waning title challenge, made him a hero once more for supporters who wanted him 'rot in the reserves'. Then there were the antics of Mario Balotelli; the fireworks on and off the pitch including several red cards and a disastrous performance against Arsenal that appeared to undermine his manager and team-mates. So often a club regarded as the punch-line of British football, Harry Harris looks at City's rise from the ashes following the influx of Mansour's millions. The FA Cup triumph that ended the club's 35-year wait for a major trophy and October's stunning 6-1 derby victory at Old Trafford appeared to signal a shift in power in Manchester. City's title win has confirmed that an exciting new era in British football is about to dawn and this book follows every kick, tantrum and controversy throughout their remarkable season.

Sir Alex Ferguson said that his brief as Manchester United manager was to "knock Liverpool off their f*****g perch". After over 2,000 games and 25 seasons, this year he finally succeeded. Following an endless supply of trophies, none meant more to United's global legion of fans than their 19th league title - simply because it finally put Liverpool in their place. It has taken Sir Alex 25 years to establish United as the leader of the championship pack. When Alan Hansen captained Liverpool to their most recent championship in 1990, the tally read 18-7 in Liverpool's favour and few would have given the Scot a prayer of capturing one championship, never mind 12. In "19", award-winning journalist Harry Harris looks back at all the title winning seasons and analyses each one from the viewpoint of a player who distinguished himself in that title year, building up to the record title and an in-depth analysis of the 2010-11 season and how United finally surpassed Liverpool. The book looks at the record through the eyes of those who took part in each of them, or who observed them from close quarters."19" features exclusive interviews with Arthur Albiston, Alan Brazil, Steve Bruce, Garth Crooks, Gary Pallister, Paul Parker, Lee Sharpe, Gordon Taylor, Dave Whelan, Ray Wilkins.

The ability to identify and abort fetuses with certain genetic abnormalities is among the most recent and most important of medical advances. In this book, one of the world's leading medical geneticists, Harry Harris, discusses the promise and the perils of the new techniques. Dr. Harris writes with great clarity; he explains technical concepts and terms so well that a layman can follow his account with little effort. This book will serve as an excellent introduction to a large and growing literature. Dr. Harris begins by explaining methods of prenatal diagnosis and the kinds of disease that can, at present, be identified in utero. He identifies technological limitations of the procedure and also discusses certain theoretical factors that limit its future applicability. The book concludes with a long and balanced examination of ethical issues entailed by the practice of selective abortion. The author limits discussion of his own opinions in favor of evaluating the main contemporary positions and exploring the basis of controversy. He makes clear, however, his own view that there are clear advantages to the technique and clear limitations and that there will always be gray areas in which decision must be painful and individual--unaided by pat moralizing.