The ascent of startups on the Fortune 500 ranking, displacing some of the more notable companies, raised not only attention but also questions. Fundamentally, startups are built on a very different organizational culture as compared to a traditional Fortune 500. Could these cultural differences be the reason startups are in the forefront of technology innovation, disrupting industries dominated by more established competitors and thriving in today’s volatile business environment? Department of Startup: Why Every Fortune 500 Should Have One aims to help CEOs, presidents, and human resource practitioners on how they can transform their large corporation to thrive in a fast, social media conscious, and unforgiving market a la startup.