Jhakeshwar Prasad

Lo scopo del presente lavoro di ricerca era la strategia sintetica per i ligandi, l'ottimizzazione delle condizioni di reazione, la progettazione della formulazione, la caratterizzazione dei composti sintetizzati e la loro valutazione per le attivit biologiche, cio le attivit antimicrobiche. Questo libro definisce il valore medicinale dei composti sintetizzati e le loro attivit biologiche. I lettori troveranno una nota esaustiva sul meccanismo e sulle azioni farmacologiche dei composti sintetici. La valutazione della tossicit dei composti sintetici fornir il livello di sicurezza del consumo per scopi medicinali. Il lavoro si basato sulla determinazione delle propriet fisico-chimiche dei composti sintetizzati contro l'attivit antimicrobica e antinfiammatoria. Spero che questo libro sia utile ai ricercatori nel campo della chimica farmaceutica, della fitochimica, della farmacologia e della biologia, e della scienza biomedica.

O objetivo do presente trabalho de pesquisa foi a estrat gia sint tica para a otimiza o da condi o de rea o dos ligandos, desenho da formula o, caracteriza o dos compostos sintetizados e sua avalia o para as atividades biol gicas, ou seja, atividades antimicrobianas. Este livro define o valor medicinal dos compostos sintetizados e suas atividades biol gicas. Os leitores encontrar o uma nota exaustiva sobre o mecanismo e as a es farmacol gicas dos compostos sint ticos. A avalia o da toxicidade dos compostos sint ticos proporcionar o n vel de seguran a do consumo para fins medicinais. O trabalho foi baseado na determina o da propriedade f sico-qu mica dos compostos sintetizados contra a atividade antimicrobiana e Anti-inflamat ria. Espero que este livro seja til para os pesquisadores no campo da Qu mica Farmac utica, Fitoqu mica, Farmacologia & Biologia, e Ci ncia Biom dica.

Celem niniejszej pracy badawczej bylo opracowanie strategii syntetycznej dla ligand w, optymalizacja warunk w reakcji, zaprojektowanie formulacji, charakterystyka zsyntetyzowanych związk w oraz ich ocena pod kątem aktywności biologicznej tj. aktywności przeciwdrobnoustrojowej. Książka ta określa wartośc leczniczą zsyntetyzowanych związk w oraz ich aktywnośc biologiczną. Czytelnicy znajdą w niej wyczerpującą informację na temat mechanizmu i dzialań farmakologicznych związk w syntetycznych. Ocena toksyczności związk w syntetycznych pozwoli określic poziom bezpieczeństwa ich spożycia w celach leczniczych. Praca zostala oparta na określeniu wlaściwości fizykochemicznych zsyntetyzowanych związk w pod kątem aktywności przeciwdrobnoustrojowej i przeciwzapalnej. Mam nadzieję, że książka ta będzie pomocna dla badaczy w dziedzinie chemii farmaceutycznej, fitochemii, farmakologii i biologii oraz nauk biomedycznych.

The aim of the present research work was to formulate the designing, the characterization, the in-vitro and in-vivo anti-inflammatory activity in rats. In this research, we have developed Acacia Arabica Microparticles and defined their medicinal value. Readers will find exhaustive notes on the mechanism and pharmacological actions of plants; the toxicity evaluation of plants and will be informed on the safety level of consumption for medicinal purposes of these plants. The work was based on determination of the therapeutic potential of plants against Anti-bacterial and Anti-inflammatory activity. The authors hope that this book will be helpful to researchers in the field of Pharmacology & Biology and Biomedical Science.

The aim of the book is to present the synthetic strategy for the ligands optimization of reaction condition, formulation designing, characterization of synthesized compounds, and their evaluation for the biological activities i.e. antimicrobial activities. This book defining the medicinal value of synthesized compounds and their biological activities. Readers will find an exhaustive note on the mechanism and pharmacological actions of synthetic compounds. Toxicity evaluation of synthetic compounds will provide the safety level of consumption for medicinal purposes. The work was based on the determination of physico-chemical property of synthesized compounds against antimicrobial and Anti-inflammatory activity. Hope this book will be helpful to the researchers in the field of Pharmaceutical Chemistry, Phytochemistry, Pharmacology & Biology, and Biomedical Science.

Depression is a psychiatric condition in which there is loss of interest in all pleasurable outlets, viz. food, sex, work, friends, hobbies and entertainment. The prevalence rate of the disease is 6-8% in women and 3-5% in men. Ayurveda is the science of life and art of possibility which provide systemic management principles for depression. Antidepressant are the drugs used for the treatment of major depressive disorders and other conditions, including dysthymia, anxiety disorder, obsessive compulsive disorder, eating disorder, chronic pain, neuropathic pain and some cases, dysmenrrhoea, snoring, migraine etc. Mamsyadi Kwatha is one such formulation in various ingredients which is said to be effective in psychiatric conditions. The ingredients of this formulation are Jatamansi (Nardostachys Jatamansi), Ashwagandh (Withania Somnifera) and Khurasani Ajwain (Hyoscyamus Niger) in an 8:4:1 ratio, respectively. The test drug was subjected for antidepressant activity in experimental models. The models selected for anti depressant activity were behavioral despair test, anti-reserpine test and Chronic Fatigue Syndrome (CFS) test in albino mice.

Diabetes mellitus is a chronic major endocrine disorder and growing health problem in most countries and is characterized by hyperglycemia, hyperlipidemia, negative nitrogen balance and sometimes ketonemia. Diabetes is one of stress-related disorders. Diabetic subjects are shown to have increased oxidative stress and decreased antioxidant levels. Antioxidants are claimed to work as antistress agents by decreasing oxidative stress. Lycopene, a carotenoid is mostly found in tomatoes and tomato products. It is a powerful antioxidant with a single-oxygen quenching capacity. It is 100 times greater than that of β-carotene and vitamin-E respectively. This book defining the alteration in the effectiveness or toxicity of one drug due to another simultaneously administered drug is known as drug-drug interaction. A drug interaction may result in adverse effects wherein there is a decrease in the effectiveness. Biological interference with laboratory tests may mislead the diagnosis. Beneficial effects, wherein there is an increase in the effectiveness or a decrease in the toxicity of one drug in the presence of another.

Curcumin are the main constituent of spices turmeric and is obtain from the rhizome of the East Indian plant Curcuma longa, family- Zingiberacae. It is one on the most promising natural products for both the biological and chemical study. Polyphenols have capacity to prevent and treatment of various disease due to their antioxidant capabilities. Polyphenols are derived from many components of the human food like turmeric. Curcumin has not only food derivatives it also shown multiple beneficial medicine properties to prevent the disease. The aim of this work was to develop and evaluate Curcumin loaded liposome and its bio- enhancement. Curcumin was selected as a natural drug for liposome formulation. Curcumin show variety of biological activity but it also shows poor bioavailability due to low aqueous solubility (1 μg/ml), poor absorption and rapid metabolism so that Piperine was selected as bio enhancer to improve curcumin bioavailability. Soy lecithin and cholesterol were used to prepared Curcumin and curcumin-piperine loaded liposome at different ratio by thin film hydration method because of easy to perform, and high encapsulation rates of lipid.

Asthma is a common long-term inflammatory disease of the airways of the lungs. It is a hypersensitivity disorder characterized by bronchospasm, excessive excretion of a viscous mucus, edema that can leads to ventilator insufficiency . The symptoms of asthma often present in periodic attacks or episodes of tightness in the chest, wheezing, breathlessness, and coughing. During the development of asthma, the airways swell and become extremely sensitive to some of the substances a person might inhale. This book defining the medicinal value of Musa Paradisiaca. Readers will find exhaustive note on mechanism and pharmacological action of plants. Toxicity evaluation of plants will provide the safety level of consumption for medicinal purposes. The work was based on determination of therapeutic potential of plants against asthma disease.