Juncheng Wei

This monograph is concerned with the mathematical analysis of patterns which are encountered in biological systems. It summarises, expands and relates results obtained in the field during the last fifteen years. It also links the results to biological applications and highlights their relevance to phenomena in nature. Of particular concern are large-amplitude patterns far from equilibrium in biologically relevant models. The approach adopted in the monograph is based on the following paradigms:• Examine the existence of spiky steady states in reaction-diffusion systems and select as observable patterns only the stable ones• Begin by exploring spatially homogeneous two-component activator-inhibitor systems in one or two space dimensions• Extend the studies by considering extra effects or related systems, each motivated by their specific roles in developmental biology, such as spatial inhomogeneities, large reaction rates, altered boundary conditions, saturation terms, convection, many-component systems. Mathematical Aspects of Pattern Formation in Biological Systems will be of interest to graduate students and researchers who are active in reaction-diffusion systems, pattern formation and mathematical biology.

This monograph is concerned with the mathematical analysis of patterns which are encountered in biological systems. It summarises, expands and relates results obtained in the field during the last fifteen years. It also links the results to biological applications and highlights their relevance to phenomena in nature. Of particular concern are large-amplitude patterns far from equilibrium in biologically relevant models. The approach adopted in the monograph is based on the following paradigms:• Examine the existence of spiky steady states in reaction-diffusion systems and select as observable patterns only the stable ones• Begin by exploring spatially homogeneous two-component activator-inhibitor systems in one or two space dimensions• Extend the studies by considering extra effects or related systems, each motivated by their specific roles in developmental biology, such as spatial inhomogeneities, large reaction rates, altered boundary conditions, saturation terms, convection, many-component systems. Mathematical Aspects of Pattern Formation in Biological Systems will be of interest to graduate students and researchers who are active in reaction-diffusion systems, pattern formation and mathematical biology.

The authors prove some refined asymptotic estimates for positive blow-up solutions to $\Delta u+\epsilon u=n(n-2)u^{\frac{n+2}{n-2}}$ on $\Omega$, $\partial_\nu u=0$ on $\partial\Omega$, $\Omega$ being a smooth bounded domain of $\mathbb{R}^n$, $n\geq 3$. In particular, they show that concentration can occur only on boundary points with nonpositive mean curvature when $n=3$ or $n\geq 7$. As a direct consequence, they prove the validity of the Lin-Ni's conjecture in dimension $n=3$ and $n\geq 7$ for mean convex domains and with bounded energy. Recent examples by Wang-Wei-Yan show that the bound on the energy is a necessary condition.