Kanika Dhote

Clonidine Hydrochloride a centrally acting sympatholytic and Imidazoline-derivative hypotensive agent; selective α2-adrenergic agonist. It stimulates alpha2-adrenergic receptors in the brain-stem to decrease sympathetic nervous system outflow. It is also administered epidurally to treat pain. It is prescribed alone or in combination for the reduction of high blood pressure and is an adjunct for the treatment of cancer pain when pain persists during intraspinal opiate treatments. It acts by stimulating alpha-adrenergic receptors in the CNS, decreasing sympathetic outflow, inhibiting vasoconstriction, and ultimately reducing blood pressure. Also prevents transmission of pain impulses by inhibiting pain pathway signals in the brain. The objective of the work was to design multiple unit dosage forms as micro beads of a drug meant for the management of anxiety and hypertensive disorder. Micro beads offer numerous advantages for releasing one of the drugs or part of the same drug immediately, while remaining drug or parts of the same can be sustained release.

Sustained drug delivery means not only prolonged duration of drug delivery, but also implies predictability and reproducibility of drug release kinetics. Most of the sustained release dosage forms (SRDF) are based on the polymers, which retard the drug release. Polymeric materials like natural acrylic and cellulose polymers have been used widely for this purpose. There are several types of gastro retentive system, but among of all these systems gastroretentive floating drug delivery system had major advantages. In this system the active content embedded in the dosage form and having a desired release mechanism with buoyancy on to the gastric fluid. These types of dosage form float in the gastric environment without effecting the gastric emptying rate and so the dosage form remain in the gastric environment for a longer period of time. During the floating stage the active content release from the dosage form at specified time and rate in the gastric environment. The objective of the work designed to develop sustained release tablets as gastrorentive drug delivery dosage form of a drug meant for the management of treat high blood pressure hypertension.