Khushboo Gupta

AI and machine learning (ML) are increasingly transforming the field of radiopharmaceutical development, offering new ways to design, optimize, and evaluate these critical compounds. Radiopharmaceuticals, which are used for both diagnostic imaging and targeted therapy, require precise formulation and testing to ensure safety and efficacy. AI and ML technologies can accelerate this process by analyzing vast amounts of complex data, identifying patterns, and making predictions that were previously time-consuming or difficult. Machine learning algorithms, such as deep learning and reinforcement learning, are used to model molecular interactions, predict the behavior of radiopharmaceuticals within the body, and optimize the selection of radioisotopes for specific targeting. AI-driven tools also enable faster drug discovery by simulating and predicting the outcomes of radiopharmaceutical interactions with biological systems, thus reducing the need for extensive trial and error.

This book titled "Handbook on Inflammatory Bowel Disease (Volume 2)" is primarily intended to be a collection of peer reviewed and plagiarism free chapters written by research scholars, academicians, scientists, doctors and faculty members of their respective fields. Chapters of this book particularly based on topics such as classification of inflammatory bowel disease, IBD and its pathophysiology and morphology, role of nosodes in the treatment of inflammatory bowel disease ant its dietary management, curative treatment of inflammatory bowel disease by allopathy, the role of immunomodulators in inflammatory bowel disease, surgical treatment for IBD, role of residue in IBD, lactose intolerance and IBD: A comprehensive overview and IBD and mental health. This book will be very useful for students all over in India and Abroad, academicians, medical doctors, dietitians, nutritionists, health care workers, public health specialists, community science specialists, community development professionals, programmers of national and international agencies as well as libraries of relevant collages and institutions.

This book entitled "Nutrition Education: An Important Pillar of Health" is the result of an initiative taken by educational YouTube Channel 'Dietitian Ki Salah' and a non-profit organization 'Jeevan Asheesh Sameeti' Kota, Rajasthan. Thirteen essays related to various areas of nutrition are compiled in this book to aware common people about different aspects of food and nutrition. This knowledge can be proved very helpful to upgrade their quality of life by utilizing it in their day today life.

L'objectif de cette recherche tait de d velopper une formulation antidiab tique combin e de deux m dicaments diff rents agissant par des m canismes diff rents. Ils peuvent ainsi se compl ter et abaisser efficacement le taux de glucose sanguin. La metformine et le glim piride agissent par des m canismes diff rents. Le glim piride r duit l'hyperglyc mie en augmentant la s cr tion d'insuline, tandis que la metformine am liore la sensibilit l'insuline et supprime la production h patique de glucose. En raison de la compl mentarit de leurs m canismes d'action, l'association du glim piride et de la metformine serait rationnelle et pourrait apporter des avantages en termes d'am lioration du contr le de la glyc mie et d'am lioration de la tol rance des doses plus faibles des agents individuels.

Ziel dieser Forschungsarbeit war es, eine kombinierte antidiabetische Formulierung aus zwei verschiedenen Arzneimitteln zu entwickeln, die ber unterschiedliche Mechanismen wirken. So k nnen sie sich gegenseitig erg nzen und gemeinsam den Blutzuckerspiegel wirksam senken. Metformin und Glimepirid wirken ber unterschiedliche Mechanismen. Glimepirid reduziert die Hyperglyk mie, indem es die Insulinsekretion steigert, w hrend Metformin die Insulinempfindlichkeit verbessert und die hepatische Glukoseproduktion unterdr ckt. Aufgrund ihrer komplement ren Wirkmechanismen w re eine Kombinationstherapie mit Glimepirid und Metformin sinnvoll und k nnte zu Vorteilen in Form einer verbesserten Blutzuckerkontrolle und einer besseren Vertr glichkeit bei niedrigeren Dosen der einzelnen Wirkstoffe f hren.

L'obiettivo di questa ricerca stato quello di sviluppare una formulazione antidiabetica combinata di due diversi farmaci che agiscono con meccanismi diversi. In questo modo possono completarsi a vicenda e insieme abbassare efficacemente il livello di glucosio nel sangue. La metformina e la glimepiride agiscono con meccanismi diversi. La glimepiride riduce l'iperglicemia aumentando la secrezione di insulina, mentre la metformina agisce migliorando la sensibilit all'insulina e sopprimendo la produzione epatica di glucosio. A causa del loro meccanismo d'azione complementare, la terapia combinata con glimepiride e metformina sarebbe razionale e potrebbe portare a benefici in termini di miglioramento del controllo glicemico e della tollerabilit a dosi inferiori dei singoli agenti. La somministrazione sostenuta del farmaco pu migliorare la compliance del paziente e contribuire a mantenere un livello efficace di glucosio nel sangue.

O objetivo desta investiga o foi desenvolver uma formula o antidiab tica combinada de dois medicamentos diferentes que actuam por mecanismos diferentes. Assim, podem complementar-se mutuamente e, em conjunto, baixar eficazmente o n vel de glucose no sangue. A metformina e a glimepirida actuam por mecanismos diferentes. A glimepirida reduz a hiperglicemia aumentando a secre o de insulina, enquanto a metformina actua para melhorar a sensibilidade insulina e suprimir a produ o hep tica de glicose. Devido ao seu mecanismo de a o complementar, a terap utica combinada com glimepirida e metformina seria racional e poderia conduzir a benef cios em termos de melhor controlo glic mico e melhor tolerabilidade com doses mais baixas dos agentes individuais.

Embark on a journey into the heart of motherhood with "Nurturing Bonds: A Holistic Guide to Breastfeeding Bliss". This comprehensive book unravels the intricacies and complexities of the breastfeeding journey from the emotional dance between mother and child to the societal and global factors influencing this universal practice. This book goes beyond feeding babies; it explores the feelings between mothers and little ones, the changes happening inside both and how society plays a part. It's not just about food - its about a special connection. Packed with practical advice, and enlightening facts and a celebration of the enduring connections formed through breastfeeding; this book invites readers to broaden their horizons and appreciate the diverse and beautiful complexities of parenthood with a reminder that the breastfeeding is more than a biological function - it's a celebration of life, love and the enduring bonds that tie us together.

Le acque sotterranee svolgono un ruolo importante nell'agricoltura indiana Con l'aumento della domanda di acque sotterranee inevitabile un incremento delle emissioni di gas serra per l'ulteriore estrazione di acqua sotterranea dalle falde acquifere in diminuzione. Gli agricoltori pompano le acque sotterranee per produrre colture di successo, il che richiede un maggiore consumo di energia. Il consumo di energia e le emissioni di gas serra sono una delle principali preoccupazioni dei Paesi in via di sviluppo. Nel presente studio sono stati studiati il consumo di energia e le emissioni di carbonio attraverso l'estrazione di acqua di falda in diversi distretti dello stato di Bihar. stato inoltre studiato l'impatto di diverse opzioni di gestione dell'acqua sul prelievo totale annuo di acque sotterranee, sul consumo energetico e sulle emissioni di carbonio. Sono stati considerati diversi scenari di gestione dell'acqua per la conservazione dell'energia e la riduzione delle emissioni di carbonio.

Les eaux souterraines jouent un r le important dans l'agriculture indienne. Avec l'augmentation de la demande en eaux souterraines, l'augmentation des missions de gaz effet de serre et la poursuite du pr l vement d'eaux souterraines dans des nappes phr atiques en d clin sont in vitables. Les agriculteurs ont pomp les eaux souterraines pour assurer la r ussite de la production agricole, ce qui exige une plus grande consommation d' nergie. La consommation d' nergie et les missions de gaz effet de serre sont l'une des principales pr occupations des pays en d veloppement. Dans cette tude, la consommation d' nergie et l' mission de carbone par l'extraction d'eau souterraine dans diff rents districts de l' tat de Bihar ont t tudi es. L'impact de diff rentes options de gestion de l'eau sur le pr l vement annuel total des eaux souterraines, la consommation d' nergie et l' mission de carbone a galement t tudi . Diff rents sc narios de gestion de l'eau ont t envisag s pour la conservation de l' nergie et la r duction des missions de carbone.

Grundwasser spielt in der indischen Landwirtschaft eine wichtige Rolle. Mit der zunehmenden Nachfrage nach Grundwasser steigt auch der Aussto von Treibhausgasen, denn die weitere Entnahme von Grundwasser aus dem gesunkenen Grundwasserspiegel ist unvermeidlich. Die Landwirte pumpen Grundwasser f r eine erfolgreiche Pflanzenproduktion, was einen h heren Energieverbrauch erfordert. Der Energieverbrauch und die Treibhausgasemissionen sind eines der wichtigsten Anliegen der Entwicklungsl nder. In der vorliegenden Studie wurden der Energieverbrauch und die Kohlenstoffemissionen durch Grundwasserentnahme in verschiedenen Bezirken des Staates Bihar untersucht. Die Auswirkungen verschiedener Wasserbewirtschaftungsoptionen auf die gesamte j hrliche Grundwasserentnahme, den Energieverbrauch und die Kohlenstoffemissionen wurden ebenfalls untersucht. F r die Energieeinsparung und die Verringerung der Kohlenstoffemissionen wurden verschiedene Wasserbewirtschaftungsszenarien in Betracht gezogen.

As guas subterr neas desempenham um papel importante na agricultura indiana Com o aumento da procura de guas subterr neas, inevit vel o aumento da emiss o de gases de estufa para uma maior extrac o de guas subterr neas dos len is fre ticos em decl nio. Os agricultores t m vindo a bombear gua subterr nea para uma produ o agr cola bem sucedida que exige um maior consumo de energia. O consumo de energia e a emiss o de gases com efeito de estufa s o uma das preocupa es importantes do pa s em desenvolvimento. No presente estudo foi estudado o consumo de energia e a emiss o de carbono atrav s da capta o de guas subterr neas em diferentes distritos do estado de Bihar. Foi tamb m estudado o impacto de diferentes op es de gest o da gua no projecto total anual de guas subterr neas, consumo de energia e emiss o de carbono. Foram considerados diferentes cen rios de gest o da gua para a conserva o de energia e redu o das emiss es de carbono.