Malika Arora

Probiotics is a broad term used for friendly bacteria, more appropriately defined as live microorganisms, which when administered in adequate amounts confer a health benefit on the host. These are increasingly used as food as well as pharmaceuticals due to their wide range of health benefits accompanied with low cost and negligible side effects. The tremendous growth of probiotic products in the global market has necessitated encountering formidable challenges posed due to lack of appropriate regulatory standards. For acceptance of probiotics based products with uniform quality, greater safety of patients, with established scientific evidences for holistic therapeutic benefits in treatment of various ailments, drafting of comprehensive regulatory guidelines is the need of the hour. The proposed work is to take lead in current international scenario by framing a comprehensive and harmonized guideline to be accepted universally.

A significant increase in the HSP 70 protein expression in the subjects doing regular deep breathing exercises especially Sudarshan Kriya Yoga has been observed. The expression of the same protein was comparable to the subjects living their life moderately i.e. who are not doing any kind of deep breathing exercises. Expression of HSP 70 was found to be increased significantly in all the age groups considered under study. In the present study, it was also observed that expression of HSP 70 depends upon the intensity and time duration of the exercises. Extracellular HSP 70 is present in both healthy as well as diseased subjects. HSP 70 plays dual role in the body as in the healthy it serves many different roles like in immune regulation as well as cytoprotective roles, whereas in case of diseased, extracellular HSP70 acts as a danger signal to immune cells, promote immune response and improves host defense. HSP comes out via cell lysis in case of diseased, whereas, in the healthy subjects doing regular physical activity it comes out via secretory pathways in which exosomes provide a secretory vesicle facilitating the exocytosis of HSP which is beneficial for the body.