Mohamed F Alajmi

Globally, millions of deaths are reported annually due to cancers, bacterial, fungal, viral and parasitic diseases, diabetes and inflammatory conditions. Metal complexes have been extensively developed and tested for anticancer, antibacterial, antifungal, antiviral, antiparasitic, antidiabetic and anti-inflammatory properties. It is quite encouraging to learn that quite a lot of metal complexes with interesting therapeutic properties have been developed. This concise book reviews the recent advances made in the development of gold complexes as therapeutics, highlighting the different ligand architectures that have been used for their development. The mechanisms of therapeutic action, the development of nanodrugs and the toxicity issues of gold complexes are all discussed in detail. Finally, the book reflects on the future research and development in gold complexes as therapeutic agents. Postgraduates and researchers in drug discovery and development interested in metal-based therapeutics and biomedical applications of gold will find this book enlightening.

This book describes the emergence and recent advances in the design and development of rhodium complexes as therapeutic agents. Different classes of anticancer rhodium complexes with particular emphasis on ligands containing nitrogen-oxygen donor atoms are presented. Anticancer rhodium complexes of N-heterocyclic carbenes are described, while half-sandwich, heterobimetallic, and multinuclear rhodium complexes are discussed. Therapeutic applications of rhodium complexes beyond cancer such as antibacterial agents or antiviral agents are also analyzed, among others. Their mechanism of action is overviewed in detail, and the authors thoroughly comment on the challenges and future outlooks of research in the development of rhodium metallodrugs. This title highlights the important research carried out in the development of therapeutic rhodium complexes and is of great interest to graduates and researchers working in the area of rhodium-based therapeutic drugs.