Mushtaq Ahmad Lone

This book describes the emergence and recent advances in the design and development of rhodium complexes as therapeutic agents. Different classes of anticancer rhodium complexes with particular emphasis on ligands containing nitrogen-oxygen donor atoms are presented. Anticancer rhodium complexes of N-heterocyclic carbenes are described, while half-sandwich, heterobimetallic, and multinuclear rhodium complexes are discussed. Therapeutic applications of rhodium complexes beyond cancer such as antibacterial agents or antiviral agents are also analyzed, among others. Their mechanism of action is overviewed in detail, and the authors thoroughly comment on the challenges and future outlooks of research in the development of rhodium metallodrugs. This title highlights the important research carried out in the development of therapeutic rhodium complexes and is of great interest to graduates and researchers working in the area of rhodium-based therapeutic drugs.

The book is divided into four main parts; introduction, experimental, theoretical and results-discussion section. In this book we have presented in detail solubilization aspects of two solubilizates antioxdant Rutin and radical DPPH (2,2-diphenyl-1-picrylhydrazyl) in micellar structures of varied architecture followed by evaluation of DPPH radical scavenging activity of Rutin in these model self-assembled systems. Cationic surfactants proved to be efficient solubilizers for both Rutin and DPPH. The solubilizates (Rutin & DPPH) were then allowed to react in solubilized state to understand the impact of microheterogeneous environments on DPPH activity of Rutin. The radical scavenging activity of Rutin in the solubilized form was higher within ionic micelles than in nonionic micelles. The book focuses special attention on use of mixed binary surfactant systems on solubilization and DPPH activity of Rutin. It is believed that the results presented in this book would be helpful in devising surfactant based formulations to improve aqueous bio-availability of natural, hydrophobic flavonoid antioxidants, and understand mechanism of their antioxidant action in complex biological systems.