Priyanka Yadav

O livro intitulado "Estudos computacionais entre o composto metalo-farmac utico" inclui o campo da ci ncia que combina a matem tica com a qu mica chamado de qu mica computacional. respons vel pela obten o de uma rela o denominada rela o estrutura-propriedade quantitativa (QSPR) ou rela o de trabalho estrutural (QSAR). QSAR, a terminologia mais utilizada com base num m todo de comunica o em rede (SAR). QSAR o estudo de como as propriedades f sico-qu micas de uma s rie de compostos afectam a sua actividade biol gica. As caracter sticas f sico-qu micas ou defini es te ricas de mol culas qu micas ou de f rmacos s o medidas ou calculadas e estas est o relacionadas com fun es biol gicas utilizando c lculos matem ticos. Existem muitos programas de software que ajudam a obter estat sticas, mas cabe ao qu mico m dico decidir quais os dados a introduzir. Obviamente, a fun o biol gica de cada composto deve ser inclu da, mas o farmac utico deve determinar quais as caracter sticas f sicas que podem ser mais importantes para a actividade biol gica.

Le livre intitul "Computational studies among the Metallopharmaceuticals compound" comprend un domaine scientifique qui combine les math matiques et la chimie, appel chimie computationnelle. Elle est responsable de l'obtention d'une relation appel e relation quantitative structure-propri t (QSPR) ou relation structure-travail (QSAR). QSAR, la terminologie la plus utilis e, repose sur une m thode de communication en r seau (SAR). La QSAR est l' tude de la mani re dont les propri t s physicochimiques d'une s rie de compos s affectent leur activit biologique. Les caract ristiques physico-chimiques ou les d finitions th oriques des mol cules chimiques ou m dicamenteuses sont mesur es ou calcul es, puis mises en relation avec les fonctions biologiques l'aide de calculs math matiques. Il existe de nombreux logiciels qui permettent d'obtenir des statistiques, mais c'est au chimiste m dical de d cider des donn es saisir. Il est vident que la fonction biologique de chaque compos doit tre incluse, mais le pharmacien doit d terminer quelles caract ristiques physiques peuvent tre les plus importantes pour l'activit biologique.

Il libro intitolato "Studi computazionali tra i composti metallofarmaceutici" comprende il campo della scienza che combina la matematica con la chimica, chiamato chimica computazionale. Si occupa di ottenere una relazione chiamata relazione quantitativa struttura-propriet (QSPR) o relazione strutturale di lavoro (QSAR). QSAR, la terminologia pi utilizzata, si basa su un metodo di comunicazione in rete (SAR). Il QSAR lo studio di come le propriet fisico-chimiche di una serie di composti influenzino la loro attivit biologica. Vengono misurate o calcolate le caratteristiche fisiochimiche o le definizioni teoriche delle molecole chimiche o dei farmaci, che vengono messe in relazione con le funzioni biologiche mediante calcoli matematici. Esistono molti programmi software che aiutano a ottenere statistiche, ma spetta al chimico medico decidere quali dati inserire. Ovviamente, la funzione biologica di ogni composto deve essere inclusa, ma il farmacista deve determinare quali caratteristiche fisiche possono essere pi importanti per l'attivit biologica.

The book entitled "Computational studies among the Metallopharmaceuticals compound" include field of science that combines mathematics with chemistry is called computational chemistry. It is responsible for obtaining a relationship called quantitative structure-property relationship (QSPR) or structural work relationship (QSAR). QSAR, the most widely used terminology based on a network communication (SAR) method. QSAR is the study of how the physicochemical properties of a series of compounds affect their biological activity. Physiochemical features or theoretical definitions of chemical or drug molecules are measured or calculated and these are related to biological functions using mathematical calculations. There are many software programs that help to obtain statistics, but it is up to the medical chemist to decide which data to enter. Obviously, the biological function of each compound should be included, but the pharmacist should determine which physical features may be most important for biological activity.

The preformulation studies involves description, solubility, melting point, of the drug were found to be comparable with the standard. Based on the all above preformulation studies the drug was suitable for making the transdermal formulation. Based on all these factors the transdermal drug delivery system F5 was having greater % drug release. The formulation F5 shows better extended release up to 24hrs when compared to other formulations. So it was concluded that the formulation F5 prepared by using Eudragit RS100 and HPMC is the better formulation for control release of drug up to 24hrs of time. However, the best formulation F-5 follows first order kinetics and the mechanism of diffusion. Results of the present study encouraged that it can be used as controlled drug delivery system and frequency of administration can be minimized.

In the present research work, an attempt has been made to optimize and formulate bilayer tablet of saxagliptin and repaglinide to achieve immediate release of saxagliptin and sustained release of repaglinide. Saxagliptin is DPP-4 inhibitor and belonging to BCS class 1 (high solubility, high permeability). It has long half life, so an attempt was made to achieve its fast action by making immediate release tablet by using superdisintegrant sodium starch glycolate.. Repaglinide is an oral blood glucose-lowering drug of the maglitinide class used in the management of type 2 diabetes mellitus. It is absorbed by oral route and has short half life, so an attempt has been done to make sustained release tablet of repaglinide And it was concluded that the optimized formula RG4 (75 mg) drug (98.6 %) in 12 hrs. So by taking both optimized formulation in fixed dose combination in different layer. A bilayer tablet was prepared with 50 mg saxagliptin and 500 mg of repaglinide.

Bilayer tablet has been made and evaluated. For various precompression and post compression parameter. Precompression parameter shows that the granules and blends of repaglinide and saxagliptin have good Carr's index and hausner's ratio indicate that both granules and blends were free flowing. The angle of repose shows that granules and blends have excellent flow and post compression parameter show that bilayer tablet have thickness hardness and weight and friability within the I. P. limit and bilayer tablet have swelling index 82% in 6 hrs and have drug release first layer of saxagliptin release 98.6% in 30 minutes and second layer repaglinide release 95.5% in 12 hrs.

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