Ramesh Chandra

This book provides a comprehensive overview of the biochemical processes essential to human life, exploring the structure and function of biomolecules. It covers metabolic pathways, enzyme kinetics, and molecular genetics, emphasizing the biochemical basis of health and disease. The text includes laboratory techniques, clinical correlations, and applications to medical practice. Emphasis is placed on understanding the molecular mechanisms underlying physiological functions and their alterations in pathological conditions.

Molecular immunology techniques unpack the molecular machinery of immune responses using modern laboratory methods. This book begins with an accessible primer on immune cell types and signaling pathways, then transitions into hands-on protocols: PCR-based assays, flow cytometry panels, ELISAs, single-cell sequencing, and CRISPR editing for immune targets. Each protocol includes reagent lists, stepwise instructions, common pitfalls and troubleshooting tips, plus guidance on experimental design and controls to ensure reproducible results. Data analysis chapters cover gating strategies, normalization, and statistical interpretation for immunology datasets. Safety, biosafety level considerations, and ethical use of samples are emphasized throughout. It's an essential lab companion for immunologists, molecular biologists, and advanced students.

Volume 2 translates foundational biochemistry into organ-system applications and diagnostic problem-solving used in everyday clinical practice. It organizes systemic biochemical pathways—hepatic metabolism, renal handling of solutes, endocrine metabolic effects, and cardiac energetics—alongside disease-associated biochemical derangements. Practical chapters cover interpretation of metabolic panels, inborn errors, toxicology screens, and biomarkers used in cardiometabolic, hepatic, and renal disease management. Case examples illustrate how biochemical reasoning guides therapy, monitoring, and prognostication. The book also highlights advances in clinical proteomics, metabolomics, and personalized medicine that affect biochemical diagnostics. An essential clinical companion for physicians, laboratorians, and students applying biochemistry at the bedside.

Medical biochemistry explains how molecules and biochemical pathways sustain life and how their perturbations produce disease. This first handbook focuses on core metabolic pathways, enzyme kinetics, intermediary metabolism, and the molecular mechanisms underlying inherited and acquired metabolic disorders. It presents laboratory methods used to measure metabolites and enzyme activities and interprets common biochemical test results in clinical contexts. Chapters discuss metabolic regulation, hormonal integration, and biochemical bases of nutrition and energy homeostasis. Clear diagrams and clinical correlation boxes connect molecular detail to diagnostic clues and treatment rationale. Perfect for medical students, clinical chemists, and trainees seeking a compact biochemical primer.

At the heart of modern medicine lies the molecular language that dictates cellular function, metabolism, and heredity. This textbook integrates core biochemical pathways, gene expression regulation, and genetic variation with clinical implications across specialties. It explains enzymology, metabolic networks, nucleic-acid structure and function, and principles of genomics and proteomics in clear, clinically relevant terms. Laboratory techniques — PCR, sequencing, Western blot, and CRISPR basics — are described alongside examples of diagnostic and therapeutic applications. Ethical, counseling, and translational aspects of genetics (carrier screening, pharmacogenomics) are addressed to bridge bench and bedside. Ideal for medical students, laboratory scientists, and clinicians seeking a compact molecular foundation.

This book aims to provide a detailed exploration of the structure and function of cells and their molecular components. It covers the fundamental concepts of cell biology, including cell structure, signaling, and division. The book also addresses molecular biology techniques and their applications in research and medicine. It is intended for students, researchers, and educators in the life sciences, offering comprehensive insights into cellular and molecular processes. By enhancing understanding of cell and molecular biology, the book seeks to advance scientific knowledge and its applications in health and disease.

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Gene silencing mediated through short interfering RNAs (siRNAs) is rapidly emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability in physiological conditions limits its therapeutic potential, hence there arises a need to develop a delivery system which can protect and efficiently transport siRNA to the target cells. Nanotechnology based non-viral vectors have been proposed as a potential alternate. Various polymeric nanoparticles have been shown as suitable delivery candidates with high cellular uptake efficiencies and advantage of reduced cytotoxicity. These delivery vectors form condensed complexes with siRNA which in turn provides protection to siRNA from enzymatic degradation and further leads to enhanced tissue and cellular targeting. Nanoparticles prepared from various polymers like polyethylenimine, chitosan have been largely exploited, as they bear several advantages such as, easy manipulatibility, high stability, low cost and high payload. Though numerous publications have appeared in the literature, there was still need to get more information under one roof, as book compilation which could provide a systematic account of all the aspects of nanotechnology mediated gene silencing right from the preparation of nanoparticles to in vitro and in vivo characterization followed by various applications in vitro and in vivo models. This book focuses on various aspects of nanotechnology based gene silencing. The initial chapters detail the techniques available for in vitro and in vivo characterization of nanoparticles. In the later chapters, exhaustive details about various polymeric systems employed for gene silencing has been accounted. The important topics discussed in the book include:-• Introduction to Nanotechnology• Physicochemical? Characterization of Nanoparticles• In Vitro and In Vivo Characterization of Nanoparticles• Concept and Barriers to Gene Silencing• Nanoparticles Mediated Targeted siRNA delivery• Polymers for siRNA Delivery• Chitosan• Polyethylenimine• Poly-L-lysine• Atelocollagen• Protamine• Dendrimers• Cyclodextrin• Poly (D, L-lactide-co-glycolide)• Nanomaterials for siRNA delivery; Keyword Index

This book explores the ideas of nine renowned economists to present the evolution of economic thought on the development and trajectory of capitalism as a system. The author shows how this diverse group of thinkers are linked by their thinking on the future role of capitalism in society and fleshes out the influences informing each economist’s work. With chapters dedicated to Karl Marx, Joseph Schumpeter, Thorstein Veblen, Henry George, Gunnar Myrdal, Alfred Marshall, Allyn Young, J. M. Keynes and Amartya Sen, the book aims to analyse contrasting views on the future of capitalism in historical perspective and make a critical assessment of their insights in contemporary contexts. While considering the views of some thinkers such as Marx, Schumpeter, and Veblen who critiqued capitalism, the book does not view capitalism beyond redemption, nor is meant to be a critique of capitalism in its conclusions. Rather, it argues that thinkers like Marshall, Myrdal, Young and Keynes were more right in their optimism about the future prospects of capitalism than many others. It argues that capitalism can be reformed through the democratic process in a more humane direction. This can happen if democracy works for all, and if discriminating privileges and crony capitalism are eschewed. This book is valuable reading for scholars and students of economic history and the history of economic thought.

Covalent bonds are a fundamental concept in chemistry. They represent strong connections between atoms formed by sharing electron pairs. These bonds are crucial in shaping molecules' structures, properties, and reactivity. Through covalent bonding, atoms achieve stable electron configurations, resulting in various compounds and materials with unique traits. Studying covalent bonds offers valuable insights into chemical bonding intricacies. It helps scientists design new molecules, comprehend chemical reactions, and develop materials for different uses. The Study and Use of Covalent Bonds in Chemistry: New Insights and Old Knowledge is a comprehensive book that explores covalent bonding. It provides historical context, foundational principles, and current research, offering a deep understanding of these fundamental interactions. By explaining molecular structure, bond energy, and bond polarity intricacies, it helps readers grasp covalent bonds' remarkable properties. Covering topics like molecular orbital theory, intermolecular forces, and chemical reactions, the book demonstrates covalent bonds' versatility and practical applications in various scientific areas.

Targeted at biology undergraduates, this book covers themes such as cell structure, function, molecular biology, and the fundamental principles of cellular biology. It provides a foundational understanding of cellular biology, which is essential for students pursuing careers in the life sciences. Practitioners in biology and related fields deepen their knowledge of cellular processes, making it a valuable resource for professionals engaged in biological research and applications. Policymakers can draw from this knowledge to inform policies related to scientific research and education, and the general public gains insights into the fundamental building blocks of life and the role of cells in living organisms.

The objective of the book Biodiversity Basics: Celebrating Life's Variety is to raise awareness and appreciation for the richness and importance of Earth's biodiversity. Through its pages, readers are taken on a journey to explore the incredible variety of species, ecosystems, and interactions that make up our planet's web of life. The book aims to educate and inspire individuals to become advocates for biodiversity conservation and sustainable living. It delves into the significance of biodiversity in providing essential ecosystem services, fostering resilience, and contributing to human well-being. Ultimately, Biodiversity Basics seeks to ignite a sense of wonder and responsibility towards protecting and preserving our planet's precious biodiversity for future generations.

""रमेश चंद्र हिंदी के अत्यंत प्रभावशाली शिल्पकार हैं । कहानी बुनने और कथानक को विश्वसनीयता के साथ आत्मीय बनाने के लिए रचनाकार की सूक्ष्म दृष्टि और मानवीय मूल्य की सकारात्मकता बेहद जरूरी होती है। इस एतबार से चंद्र स्वाभाविक रूप से हमें पारंगत नजर आते हैं। सबसे बड़ी विशेषता कहानी की पठनीयता होती है। चंद्र निस्संदेह अपनी पीढ़ी के ऐसे रचनाकार हैं, जिनमें बखूबी यह हुनर है। कहानी भी समाज का आईना होती है। और जब तक हमारा चेहरा साफ-साफ नहीं दिखता, हम आईने पर यकीन नहीं कर सकते। "भिखना पहाड़ी ' में शीर्षक कथा के अलावा अन्य कहानियों--ऊँघती उँगलियाँ और लाली लौट गई कमासुत, कसूर क्या था ? कैसे मरद हो जी ?, घंटाघर, जामुन की जड़, तेरी बेटी, तू जाने दरकती दीवारें और जीरो माइल से गुजरते हुए जिंदगी के कई रंग रोशन होते हैं ।साँसों के निरंतर आरोह-अवरोह की तरह जिंदगी भी हर जगह अपनी सुविधा और शर्तों पर चलती है। ऐसे में हमारा गहन तजुर्बा ही रचनात्मकता के आवरण में ढलकर कोई जीवंत आकृति उकेर सकता है। यही जज्बा रमेश चंद्र की प्रायः सभी कहानियों में मौजूद है। चंद्र ने वक्]त की नब्ज पहचानी है। कहानियाँ ऐसे मोड़ पर अवश्य ठहरती हैं, जहाँ हमें संभावनाओं के कई रास्ते नजर आते हैं। अपने कथा-परिवेश को चंद्र ने व्यापक बना दिया है। हम समझते हैं कि हिंदी के अलावा इन कहानियों को विभिन्]न भाषाओं में अवश्य स्थानांतरित होना चाहिए, क्योंकि विषय और कथानक की दृष्टि से ये बदलती दुनिया की बेहद मार्मिक कहानियाँ हैं ।-डॉ. कासिम खुरशीद, अंतरराष्ट्रीय शायर, लेखक ओर शिक्षाविद्], मो.: 9334079876

In recent decades, new endogenous growth theory has become popular but the ideas are not new. They go back at least as far as Adam Smith, and the subsequent contributions made notably by Alfred Marshall and Allyn Young. This book critically discusses and provides an historical perspective to the entire spectrum of endogenous growth theories starting with Adam Smith and ending with Paul Romer. It fills an important gap in the literature. While contributions of individual authors are readily available, there is no comprehensive study on the subject covering such a vast ground, critically discussing these authors in a comprehensive framework. It collates all the arguments and economic viewpoints in one collection, providing both the seasoned economist and a graduate economist with a critical comparison of origin, mechanisms, conclusions, and policy implications of these models.

La nanom decine est un domaine en pleine expansion des sciences pharmaceutiques qui permet de g n rer des m dicaments de nouvelle g n ration pour la pr vention et le traitement des maladies humaines. Les nanoparticules d'argent sont largement utilis es en raison de leurs activit s antimicrobiennes, antivirales et anticanc reuses. En outre, les nanoparticules d'argent sont galement employ es dans des produits de consommation comme l' lectronique, les peintures, les v tements, l'alimentation et les dispositifs m dicaux. Les nanoparticules d'argent ont parcouru un long chemin pour arriver au chevet des patients.