Ramesh Yamgar

A rea o de Mitsunobu muito importante para a s ntese de ter a partir de fenol e lcool. O 7-metoxi-2-(4-metoxifenil)-1-benzofurano-5-il]metanol (2) foi sintetizado a partir da vanilina utilizando uma s rie de rea es conhecidas, tais como a rea o de Mannich, acetila o, hidr lise, rea o de Wittig e hidrogena o. Este derivado de metanol benzofurano (2) condensou com 4-fluorofenol utilizando DEAD em THF. O produto final 5- (4-fluorofenoxi)metil]-7-metoxi-2-(4-metoxifenil)-1-benzofurano (3) foi caracterizado utilizando IR, NMR e espectros de massa e estudou-se a sua atividade biol gica atrav s de acoplamento molecular utilizando o software de acoplamento molecular Glide. A atividade do ter (3) foi comparada com a do seu an logo amina.

Reakcja Mitsunobu jest bardzo ważną reakcją w syntezie eteru z fenolu i alkoholu. 7-metoksy-2-(4-metoksyfenylo)-1-benzofuran-5-ylo]metanol (2) zostal zsyntetyzowany z waniliny przy użyciu serii znanych reakcji, takich jak reakcja Mannicha, acetylacja, hydroliza, reakcja Wittiga, uwodornienie. Ta pochodna benzo-furanu metanolu (2) skondensowala się z 4-fluorofenolem przy użyciu DEAD w THF. Ostateczny produkt 5- (4-fluorofenoksy)metylo]-7-metoksy-2-(4-metoksyfenylo)-1-benzofuran (3) scharakteryzowano za pomocą IR, NMR i widm masowych, a jego aktywnośc biologiczną zbadano za pomocą dokowania molekularnego przy użyciu oprogramowania Glide. Aktywnośc eteru (3) por wnano z jego analogiem aminowym.

La reazione di Mitsunobu molto importante per la sintesi dell'etere dal fenolo e dall'alcol. Il 7-metossi-2-(4-metossifenil)-1-benzofuran-5-il]metanolo (2) stato sintetizzato dalla vanillina utilizzando una serie di reazioni note quali la reazione di Mannich, l'acetilazione, l'idrolisi, la reazione di Wittig e l'idrogenazione. Questo derivato del metanolo benzofurano (2) stato condensato con 4-fluorofenolo utilizzando DEAD in THF. Il prodotto finale 5- (4-fluorofenossil)metil]-7-metossi-2-(4-metossifenil)-1-benzofurano (3) stato caratterizzato mediante IR, NMR e spettri di massa e ne stata studiata l'attivit biologica mediante docking molecolare utilizzando il software di docking molecolare Glide. L'attivit dell'etere (3) stata confrontata con quella del suo analogo amminico.

There are three main stages of research methodology; such as innovation, optimization and studies of its scope and limitations. The discovery requires extensive knowledge and experience with chemical reactivities of appropriate reagents. The optimization consists of the study of one or two starting compounds involved in the reaction under different conditions of temperature, solvent, reaction time, etc. until the setting up of optimum conditions for product yield and purity. Schiff bases have been playing a significant part in the development of coordination chemistry. Quinoline Schiff base metal complexes have been studied extensively because of their attractive chemical and physical properties and their wide range of applications in numerous scientific areas. These kind of complexes have been rigorously studied in recent times. Many of them are centered on the catalytic activity of Schiff base complexes in a large number of homogeneous and heterogeneous reactions.