Sanjay Kumar Pandey

The present book explores the molecular genetics level research of Sickle syndrome, Thalassemia and Iron Deficiency Anemia which was done at department of Hematology, All India Institute of Medical Sciences, New Delhi & APS University Rewa, Madhya Pradesh. Research was funded by Indian Council of Medical Research, New Delhi. Understanding the parameters that modify sickle cell disease severity, enormously useful in treatment decisions. A method to identify patients with prognoses for severe disease allow targeted use of the drug for people who stand most to benefit. The data of study help us to understand more about the status of phenotypic effect in sickle cell anemia patient's population in relation to molecular aspects of sickle cell genome. Pathophysiology of IDA may be altered through the metabolism of iron status with significant differences between heterozygous and those homozygous for the wild-type allele. Effect of HFE, Tf and GST mutation on the phenotype of IDA patients correlate the modulation of IDA and their genetic variation.

Sickle cell first reported by James B Herrick; (Herrick 1910) a Chicago cardiologist and professor of medicine United States, in red blood cells. The disease was named "sickle-cell anaemia" by Verne Mason in 1922, then a medical resident at Johns Hopkins Hospital.(Konotey-Ahulu 2004) However, some elements of the disease had been recognized earlier: A paper in the Southern Journal of Medical Pharmacology in 1846 described the absence of a spleen in the autopsy of a runaway slave.