Siddhartha Mukherjee

Pulitzer-palkittu kirjailija ja syöpälääkäri Siddhartha Mukherjee kertoo geenin tarinan perinpohjaisesti mutta lennokkaasti. Kirja lähtee liikkeelle Mendelin hernetarhasta ja päätyy moninaisten vaiheiden kautta nykyisiin geenimuokkausmenetelmiin yrittäessään selvittää arvoituksellista koodia, joka tekee meistä ihmisiä. Kirja kertoo samalla hyvin intiimin ja henkilökohtaisen tarinan, kun intialaissyntyinen Mukherjee tutkii oman sukunsa skitsofreniaa ja sen perinnöllisyyttä. Mukherjee nostaa kirjassaan esiin geenitutkimukseen liittyviä filosofisia ja eettisiä kysymyksiä. Oman osansa saavat niin rotuhygienia, kantasolututkimus kuin geeniperimän vaikutus yksilön terveyteen. Hän törmää koko ajan myös kysymykseen siitä, mikä oikeastaan on ”luonnollista”. Siddhartha Mukherjee on Pulitzer-palkittu kirjailija ja lääketieteen professori Columbian yliopistossa. Hänen kirjansa "Sairauksien keisari: Syövän elämäkerta" on julkaistu suomeksi vuonna 2016.

A magnificent, beautifully written biography of cancer - from its first documented appearances thousands of years ago through the epic battles to cure, control and conquer it to a radical new understanding of its essence.

The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History From the Pulitzer Prize-winning author of The Emperor of All Maladies--a fascinating history of the gene and "a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick" (Elle). "Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself." --Ken Burns "Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost" (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. "Mukherjee expresses abstract intellectual ideas through emotional stories... and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry" (The Washington Post). Throughout, the story of Mukherjee's own family--with its tragic and bewildering history of mental illness--reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation--from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. "A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are--and what our manipulation of those genes might mean for our future" (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. "The Gene is a book we all should read" (USA TODAY).

The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History From the Pulitzer Prize-winning author of The Emperor of All Maladies--a fascinating history of the gene and "a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick" (Elle). "Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself." -Ken Burns "Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost" (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. "Mukherjee expresses abstract intellectual ideas through emotional stories... and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry" (The Washington Post). Throughout, the story of Mukherjee's own family--with its tragic and bewildering history of mental illness--reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation--from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. "A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are--and what our manipulation of those genes might mean for our future" (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. "The Gene is a book we all should read" (USA TODAY).

Dr. Mukherjee, a celebrated cancer research doctor and author of The Gene and The Emperor of All Maladies, takes the reader on a soulful journey to discover the essence of his profession.

Essential, required reading for doctors and patients alike: A Pulitzer Prize-winning author and one of the world's premiere cancer researchers reveals an urgent philosophy on the little-known principles that govern medicine--and how understanding these principles can empower us all. Over a decade ago, when Siddhartha Mukherjee was a young, exhausted, and isolated medical resident, he discovered a book that would forever change the way he understood the medical profession. The book, The Youngest Science, forced Dr. Mukherjee to ask himself an urgent, fundamental question: Is medicine a "science"? Sciences must have laws--statements of truth based on repeated experiments that describe some universal attribute of nature. But does medicine have laws like other sciences? Dr. Mukherjee has spent his career pondering this question--a question that would ultimately produce some of most serious thinking he would do around the tenets of his discipline--culminating in The Laws of Medicine. In this important treatise, he investigates the most perplexing and illuminating cases of his career that ultimately led him to identify the three key principles that govern medicine. Brimming with fascinating historical details and modern medical wonders, this important book is a fascinating glimpse into the struggles and Eureka moments that people outside of the medical profession rarely see. Written with Dr. Mukherjee's signature eloquence and passionate prose, The Laws of Medicine is a critical read, not just for those in the medical profession, but for everyone who is moved to better understand how their health and well-being is being treated. Ultimately, this book lays the groundwork for a new way of understanding medicine, now and into the future.

Winner of the Guardian First Book Award 2011 Winner of the Pulitzer Prize for Non-fiction 2011 Shortlisted for the Duff Cooper Prize 2011 Shortlisted for the Wellcome Trust Book Prize

Selected as One of the Best Books of the 21st Century by The New York Times Winner of the Pulitzer Prize, adapted as a documentary from Ken Burns on PBS, this New York Times bestseller is "an extraordinary achievement" (The New Yorker)--a magnificent, profoundly humane "biography" of cancer. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist's precision, a historian's perspective, and a biographer's passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with--and perished from--for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer." The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

Tässä Pulizerin palkinnon saaneessa teoksessa syöpälääkäri ja tutkija Siddhartha Mukherjee tutkii syöpää solubiologin tarkkuudella, historioitsijan perspektiivistä ja elämäkerran kirjoittajan intohimolla. Tulos on selkeä kronikka ihmisen taistelusta tappajaa vastaan. Aikojen saatossa käsitys syövästä on muuttunut. Vielä sata vuotta sitten sitä koskevat tiedot olivat erittäin vähäiset ja hoito laajaa kirurgiaa. Röntgensäteiden keksimisen jälkeen toiseksi aseeksi tuli sädehoito. Ja viime vuosisadan puolivälissä löydettiin muutamia kemikaaleja, joilla voidaan käydä joitakin syövän muotoja vastaan. Syntyi kemoterapia. Kolmisenkymmentä vuotta sitten järeän hoidon rinnalle tuli saattohoito ja syöpäpotilaat saivat kuolla arvokkaasti. Samaan aikaan syöpäbiologia tutki syövän toimintaa solutasolla ja tällä hetkellä käsitys syövän luonteesta alkaa olla pääpiirteissään tiedossa. Ja ongelman valtavuus on selkiytymässä. Ihminen on oppinut hoitamaan joitakin syöpiä, viivyttämään niiden etenemistä ja ehkä jopa parantamaan joitakin syövän muotoja. Taistelu on kuitenkin vasta alussa. Siddhartha Mukherjee on lääketieteen apulaisprofessori Columbia Universityssä.

Selected as One of the Best Books of the 21st Century by The New York Times Winner of the Pulitzer Prize, adapted as a documentary from Ken Burns on PBS, this New York Times bestseller is "an extraordinary achievement" (The New Yorker)--a magnificent, profoundly humane "biography" of cancer. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist's precision, a historian's perspective, and a biographer's passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with--and perished from--for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer." The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.