Sonal Setya

CPX loaded Nanostructured lipid carrier (NLC) were successfully developed as a potential topical delivery system for the treatment of wounds. The drug and its potential excipients for NLC were screened by preformulation studies viz. organoleptic evaluation, melting point analysis, UV-Visible spectra, solubility studies, partition coefficient analysis, Fourier transform-Infrared (FT-IR) analysis and Differential Scanning calorimetric (DSC) analysis. After successful characterization of drug, formulation development was carried out for the selection and optimization of solid lipid, liquid lipid, solid lipid to liquid lipid ratio, surfactant and co-surfactant concentration, formulation technique, process parameters viz. PDI, Sonication time and EE%. The characterizations of the prepared NLC formulations were assessed by means of shape, particle size distribution, zeta potential analysis, drug entrapment efficiency, and in vitro drug release studies to select the optimized NLC formulation. The permeation study revealed that the permeability parameters were significantly higher for NLC-based gel formulation as compared to marketed formulation.