Suhas Awati

Petroleum ether (40-600C), chloroform, ethyl acetate, methanol and aqueous extracts were subjected to evaluation of the antidiabetic activity. Diabetes was induced by alloxan monohydrate. The acute and chronic study included the measurement of blood glucose level at 0, 1, 3, 5, 7, 24 hr and 15th day after administration of extracts orally. Glibenclamide was used as a standard drug. The characterization of the extract was performed by a physicochemical and phytochemical investigation. Isolation and characterization were carried out on column chromatography along with different spectroscopic methods. Result: Among all the extracts, ethyl acetate and methanol extract showed a more significant reduction in blood glucose level and biochemical parameters such as total cholesterol, triglycerides, liver enzymes viz. SGOT, SGPT, ALP and urea level and also increases the serum insulin level in extract treated diabetic rats. Conclusion: The present study concluded that the Bridelia retusa Spreng. was found to be effective herb against alloxan induced diabetes and also in preventing the metabolic alteration induced as the consequence of diabetes.

Orphan disease research has historically been highly fragmented by data type, by a research institution, and by disease. Individual efforts often have little interoperability and it can be almost impossible to connect the detailed clinical information held in one database with the genetic information held in another, or with information on whether a biomaterial sample or data from clinical research studies is available. Linking up this data at the level of an individual patient enables researchers to gain a better overview of the disease they are studying without having to collect all the information again from scratch. Providing access to data by other researchers in a secure fashion with adequate data protection allows researchers in other institutions and studying other Orphan diseases to compare results and gain new insights. By developing robust mechanisms and standards for linking and exploiting existing data and new data generated in related Orphan disease research projects, RD-Connect will develop a critical mass for harmonization and provide a strong impetus for a global "trial-ready" infrastructure.