Sunil Karale

Petroleum ether (40-600C), chloroform, ethyl acetate, methanol and aqueous extracts were subjected to evaluation of the antidiabetic activity. Diabetes was induced by alloxan monohydrate. The acute and chronic study included the measurement of blood glucose level at 0, 1, 3, 5, 7, 24 hr and 15th day after administration of extracts orally. Glibenclamide was used as a standard drug. The characterization of the extract was performed by a physicochemical and phytochemical investigation. Isolation and characterization were carried out on column chromatography along with different spectroscopic methods. Result: Among all the extracts, ethyl acetate and methanol extract showed a more significant reduction in blood glucose level and biochemical parameters such as total cholesterol, triglycerides, liver enzymes viz. SGOT, SGPT, ALP and urea level and also increases the serum insulin level in extract treated diabetic rats. Conclusion: The present study concluded that the Bridelia retusa Spreng. was found to be effective herb against alloxan induced diabetes and also in preventing the metabolic alteration induced as the consequence of diabetes.