Vikas Rana

Die vorliegende Untersuchung wurde mit dem Ziel konzipiert, Chitosan (CH)-Filme durch Vernetzung mit Natriumcitrat (Nacit), Natriumtripolyphosphat (NaTPP) oder Chondroitinsulfat (CS) zu formulieren, die in der Lage sein sollen, die in vitro-Permeation eines polaren Modellwirkstoffs, 5-Fluorouracil (5-FU), und eines unpolaren Wirkstoffs, Indomethacin (INDO), durch Ratte/Kaninchen oder menschliche Epidermis zu simulieren. Das Optimierungsdesign wurde eingesetzt, um verschiedene Prozess- und Formulierungsvariablen zu identifizieren und zu optimieren, die die Permeation beider Arzneimittel ber diese Folien signifikant (p

La pr sente tude a t con ue dans le but de formuler des films de chitosane (CH) par r ticulation avec du citrate de sodium (Nacit), du tripolyphosphate de sodium (NaTPP) ou du sulfate de chondro tine (CS) qui seront capables de simuler la perm ation in vitro d'un m dicament polaire mod le, le 5-fluorouracile (5-FU), et d'un m dicament non polaire, l'indom thacine (INDO), travers l' piderme de rat, de lapin ou d'humain. Un plan d'optimisation a t utilis pour identifier et optimiser diverses variables de processus et de formulation ayant une influence significative (p

A presente investiga o foi concebida com o objectivo de formular filmes de Chitosan (CH) por liga o cruzada com citrato de s dio (Nacit), tripolifosfato de s dio (NaTPP) ou sulfato de condroitina (CS) que devem ser capazes de simular a permea o in vitro do modelo de droga polar, 5-Fluorouracil (5-FU) e droga n o polar, Indometacina (INDO) atrav s de rato/coelho ou epiderme humana. O desenho de optimiza o foi utilizado para identificar e optimizar v rias vari veis de processo e formula o significativamente (p

La presente indagine stata progettata con l'obiettivo di formulare film di Chitosano (CH) mediante reticolazione con citrato di sodio (Nacit), tripolifosfato di sodio (NaTPP) o condroitinsolfato di condroitina (CS) che devono essere in grado di simulare la permeazione in vitro del farmaco polare modello, 5-Fluorouracile (5-FU) e farmaco non polare, Indometacina (INDO) attraverso il ratto/coniglio o l'epidermide umana. Il design di ottimizzazione stato impiegato per identificare e ottimizzare varie variabili di processo e di formulazione in modo significativo (p

Chitosan is the deacetylated form of chitin. Generally, the substance becomes soluble in dilute acids when the degree of deacetylation is more than 50%. The solubility of chitosan in dilute acids is often needed to be modified when specific drug release properties have to be tailored into the dosage form. The available toxicological data on chitosan and its modified forms appears to indicate its safety for oral use because high doses have been found to be tolerated well in rodents and rabbits. However, its local action as a haemostatic together with its ability to activate macrophages and cause cytokine release may require a careful assessment of its safety for parenteral use. This book offers the dynamics of chitosan's detailed composition.