Virender Kumar

Completely revised and updated, this fourth edition elucidates the principles of pharmaceutics, biopharmaceutics, dosage form design, and drug delivery – including emerging new biotechnology-based treatment modalities. The authors integrate aspects of physical pharmacy, chemistry, biology, and biopharmaceutics into drug delivery. With the expiration of older patents and generic competition, the biopharmaceutical industry is evolving faster than ever. Consequently, this edition of the book emphasizes the heightened focus that the recent remarkable progress in gene editing, immunotherapy, and nanotechnology has brought to the design of new drugs and diagnostic approaches along with novel dosage forms. Apart from new chapters, this edition highlights the emerging emphasis on the role of artificial intelligence (AI) in drug discovery, mRNA and antibody-based therapies, genome editing, immunotherapy, chemical kinetics, and the stability of drug products. Features: · Includes new chapters on antibody therapeutics, gene editing, and immunotherapy.· Explains newer approaches and future methods and the significance of artificial intelligence (AI) in drug discovery. · Updated sections on pharmacy mathematics, chemical kinetics, and the stability of medicinal products. · Important updates on parenteral drug products, protein and peptide treatments, and biotechnology-based pharmaceuticals to provide a contemporary perspective on drug development, delivery, and pharmaceutical sciences.· Expansion of review questions and answers to clarify concepts for students and add to their grasp of key concepts covered in this book. Although there are numerous books on pharmaceutics and dosage forms, most cover different areas of the discipline and do not provide an integrated approach. The integrated approach of this book not only provides a singular perspective of the overall field, but also supplies a unified source of information for students, instructors, and professionals, saving their time and money.•

Completely revised and updated, this fourth edition elucidates the principles of pharmaceutics, biopharmaceutics, dosage form design, and drug delivery – including emerging new biotechnology-based treatment modalities. The authors integrate aspects of physical pharmacy, chemistry, biology, and biopharmaceutics into drug delivery. With the expiration of older patents and generic competition, the biopharmaceutical industry is evolving faster than ever. Consequently, this edition of the book emphasizes the heightened focus that the recent remarkable progress in gene editing, immunotherapy, and nanotechnology has brought to the design of new drugs and diagnostic approaches along with novel dosage forms. Apart from new chapters, this edition highlights the emerging emphasis on the role of artificial intelligence (AI) in drug discovery, mRNA and antibody-based therapies, genome editing, immunotherapy, chemical kinetics, and the stability of drug products. Features: · Includes new chapters on antibody therapeutics, gene editing, and immunotherapy. · Explains newer approaches and future methods and the significance of artificial intelligence (AI) in drug discovery. · Updated sections on pharmacy mathematics, chemical kinetics, and the stability of medicinal products. · Important updates on parenteral drug products, protein and peptide treatments, and biotechnology-based pharmaceuticals to provide a contemporary perspective on drug development, delivery, and pharmaceutical sciences. · Expansion of review questions and answers to clarify concepts for students and add to their grasp of key concepts covered in this book. Although there are numerous books on pharmaceutics and dosage forms, most cover different areas of the discipline and do not provide an integrated approach. The integrated approach of this book not only provides a singular perspective of the overall field, but also supplies a unified source of information for students, instructors, and professionals, saving their time and money. •

L'equilibratura occlusale una procedura clinica volta a ottenere un'occlusione stabile, in cui le superfici occlusali dei denti interagiscono armoniosamente durante i movimenti funzionali. Questa stabilit fondamentale per distribuire in modo uniforme le forze masticatorie, riducendo cos al minimo l'usura eccessiva dei singoli denti e prevenendo un'indebita sollecitazione dell'articolazione temporo-mandibolare (ATM). Un'efficace equilibratura occlusale affronta e corregge qualsiasi interferenza occlusale per garantire interazioni fluide ed equilibrate tra i denti, migliorando cos la funzione dentale complessiva, il comfort e la salute orale a lungo termine.

L' quilibrage occlusal est une proc dure clinique visant obtenir une occlusion stable, o les surfaces occlusales des dents interagissent harmonieusement pendant les mouvements fonctionnels. Cette stabilit est essentielle pour r partir uniform ment les forces masticatoires et, par cons quent, minimiser l'usure excessive des dents individuelles et pr venir les contraintes excessives sur l'articulation temporo-mandibulaire (ATM). Un quilibrage occlusal efficace aborde et corrige toute interf rence occlusale afin de garantir des interactions harmonieuses et quilibr es entre les dents, am liorant ainsi la fonction dentaire globale, le confort et la sant bucco-dentaire long terme.

Die okklusale quilibrierung ist ein klinisches Verfahren, das darauf abzielt, eine stabile Okklusion zu erreichen, bei der die Kaufl chen der Z hne bei funktionellen Bewegungen harmonisch zusammenwirken. Diese Stabilit t ist von entscheidender Bedeutung, um die Kaukr fte gleichm ig zu verteilen und damit eine berm ige Abnutzung einzelner Z hne zu minimieren und eine berm ige Belastung des Kiefergelenks (TMJ) zu vermeiden. Eine wirksame okklusale quilibrierung behebt und korrigiert alle okklusalen Interferenzen, um ein reibungsloses, ausgewogenes Zusammenspiel der Z hne zu gew hrleisten und so die allgemeine Zahnfunktion, den Komfort und die langfristige Mundgesundheit zu verbessern.

O equil brio oclusal um procedimento cl nico que visa obter uma oclus o est vel, em que as superf cies oclusais dos dentes interagem harmoniosamente durante os movimentos funcionais. Esta estabilidade crucial para distribuir uniformemente as for as mastigat rias e, assim, minimizar o desgaste excessivo dos dentes individuais e evitar o stress indevido na articula o temporomandibular (ATM). O equil brio oclusal eficaz aborda e corrige quaisquer interfer ncias oclusais para assegurar intera es suaves e equilibradas entre os dentes, melhorando assim a fun o dent ria global, o conforto e a sa de oral a longo prazo.

A special consideration is needed for patient requiring extensive restorations for crooked teeth which is often neglected and overlooked by the dentists due to lack of specialized training. Full mouth rehabilitation provides the ultimate goal of optimum oral health to the individual and seeks to convert all unfavourable forces to the favourable ones and permit normal function, thus inducing healthy oral condition. Thus, it entails the performance of all the procedures necessary to produce a healthy, aesthetic, well-functioning, self-maintaining masticatory function. The dentist must give the specific treatment as required by the patient in full mouth rehabilitation cases like full coverage of teeth, multiple crowns, splinting of the teeth, positioning the crowns lingually or labially as required to modify the arch form, etc. Restoration of the impaired occlusion, enhancement of the aesthetics, preservation of the remaining teeth as much as possible and maintenance of a healthy periodontium. Treatment plan must result in healthy maintainability of the teeth and their respective supporting structures in harmony with the muscles, bones, joints and ligaments of the mouth and jaws.

Jo nikla hun main ab ghar se, Wapsi ka main ab kyun sochun, Mujhe abhi aur chalna hai, Mukan abhi aur baki hain, Every feeling has to owe words to arrive an expression and such an effort has been made in the form of poetry collection to touch the heart of readers. Mujhe jindgi mein har waqt, Subah ke khwab aate rahe, Jab kabhi aaine mein dekha, Udte rang najar aate rahe... Abhivyakti -Zindagi Ke Pannon se, is a collection of Hindi Poetries of two generations, of which one belongs to 1950s and other 1980s. However, one thing is common to both the generations, that is the love for poetry and this will continue for ages till the existence of civilization since the spontaneous flow of the river of human feelings & emotions can never be stopped. The best and most beautiful things in the world cannot be seen or even touched - they must be felt with the heart. - Helen Keller

Early blight is a fungal disease of tomato (Lycopersicon esculentum Mill). It is an important disease of tomato which is caused by Alternaria solani (Ellis & Mart.) and Alternaria alternate f.sp. lycopersici. Tomato crop is damaged due to severe infection of A. solani every year in India.this book gives us great pleasure to present before our readers, researchers on "Early Blight Disease of Tomato" against the early blight disease of tomato because it cover a great collections of researches, due to this information, readers will be benefitted to find out the resistance source of tomato and the resistant material found in this study is useful in the tomato improvement programme, especially for early blight disease.

This book consists of various researches which were conducted across the world and latest information has been given in this book on nutrient management aspects in chickpea. It is also extremely important to develop skill the correct soil application of micronutrient in the management of chickpea, micronutrient recommendations to mitigate micronutrient deficiencies and sustaining agricultural production system. This book will be highly useful for extension agencies, farmers, researchers including students and other stakeholders.