Wei Zhao

The main objectives of the book are to introduce the design method of boundary control strategies for the axially moving structures to reduce their vibration. This book provides the reader with a thorough grounding in the boundary controller design. Our goal is to provide advanced boundary controller design methods and their stability analysis methods and offer simulation examples and MATLAB programs for each boundary control algorithm. For each chapter, several engineering application examples are given and the contents of each chapter in this book are independent, so that readers can just read their own needs. In this book, all the control algorithms and their programs are described separately and classified by the chapter name, which can be run successfully in MATLAB. The book can benefit researchers, engineers, and graduate students in the fields of PDE modeling and boundary vibration control of flexible structures.

The main objectives of the book are to introduce the design method of boundary control strategies for the axially moving structures to reduce their vibration. This book provides the reader with a thorough grounding in the boundary controller design. Our goal is to provide advanced boundary controller design methods and their stability analysis methods and offer simulation examples and MATLAB programs for each boundary control algorithm. For each chapter, several engineering application examples are given and the contents of each chapter in this book are independent, so that readers can just read their own needs. In this book, all the control algorithms and their programs are described separately and classified by the chapter name, which can be run successfully in MATLAB. The book can benefit researchers, engineers, and graduate students in the fields of PDE modeling and boundary vibration control of flexible structures.

Develop Effective Immunogenicity Risk Mitigation StrategiesImmunogenicity assessment is a prerequisite for the successful development of biopharmaceuticals, including safety and efficacy evaluation. Using advanced statistical methods in the study design and analysis stages is therefore essential to immunogenicity risk assessment and mitigation strategies. Statistical Methods for Immunogenicity Assessment provides a single source of information on statistical concepts, principles, methods, and strategies for detection, quantification, assessment, and control of immunogenicity. The book first gives an overview of the impact of immunogenicity on biopharmaceutical development, regulatory requirements, and statistical methods and strategies used for immunogenicity detection, quantification, and risk assessment and mitigation. It then covers anti-drug antibody (ADA) assay development, optimization, validation, and transfer as well as the analysis of cut point, a key assay performance parameter in ADA assay development and validation. The authors illustrate how to apply statistical modeling approaches to establish associations between ADA and clinical outcomes, predict immunogenicity risk, and develop risk mitigation strategies. They also present various strategies for immunogenicity risk control. The book concludes with an explanation of the computer codes and algorithms of the statistical methods. A critical issue in the development of biologics, immunogenicity can cause early termination or limited use of the products if not managed well. This book shows how to use robust statistical methods for detecting, quantifying, assessing, and mitigating immunogenicity risk. It is an invaluable resource for anyone involved in immunogenicity risk assessment and control in both non-clinical and clinical biopharmaceutical development.

This book introduces high power semiconductor laser packaging design. The challenges of the design and various packaging and testing techniques are detailed by the authors. New technologies and current applications are described in detail.

Develop Effective Immunogenicity Risk Mitigation StrategiesImmunogenicity assessment is a prerequisite for the successful development of biopharmaceuticals, including safety and efficacy evaluation. Using advanced statistical methods in the study design and analysis stages is therefore essential to immunogenicity risk assessment and mitigation strategies. Statistical Methods for Immunogenicity Assessment provides a single source of information on statistical concepts, principles, methods, and strategies for detection, quantification, assessment, and control of immunogenicity. The book first gives an overview of the impact of immunogenicity on biopharmaceutical development, regulatory requirements, and statistical methods and strategies used for immunogenicity detection, quantification, and risk assessment and mitigation. It then covers anti-drug antibody (ADA) assay development, optimization, validation, and transfer as well as the analysis of cut point, a key assay performance parameter in ADA assay development and validation. The authors illustrate how to apply statistical modeling approaches to establish associations between ADA and clinical outcomes, predict immunogenicity risk, and develop risk mitigation strategies. They also present various strategies for immunogenicity risk control. The book concludes with an explanation of the computer codes and algorithms of the statistical methods. A critical issue in the development of biologics, immunogenicity can cause early termination or limited use of the products if not managed well. This book shows how to use robust statistical methods for detecting, quantifying, assessing, and mitigating immunogenicity risk. It is an invaluable resource for anyone involved in immunogenicity risk assessment and control in both non-clinical and clinical biopharmaceutical development.

This book introduces high power semiconductor laser packaging design. The challenges of the design and various packaging and testing techniques are detailed by the authors. New technologies and current applications are described in detail.

Based on extended fieldwork conducted between 2007 and 2019, this book aims to answer a simple question: What is the meaning of home for people living in vernacular settlements in rural China? This question is particularly potent since rural China has experienced rapid and fundamental changes in the twenty-first century under the influences of national policies such as "Building a New Socialist Countryside" enacted in 2006 and "Rural Revitalization" announced in 2018. Drawing upon ethnographic fieldwork, building surveys, archival research, and over 600 photographs taken by residents along with their life stories, this book uncovers the meanings of home from rural residents’ perspectives, who belong to a social group that is underrepresented in scholarship and underserved in modern China. In other words, this study empowers rural residents by giving them voice. This book links the concepts of place, home, and tradition into an overarching argument: The meaning of home rests on the ideas of tradition, including identity, consanguinity, collectivity, social relations, land ownership, and rural lifestyle. The Introduction and Chapter 4 of this book is available for free in PDF format as Open Access from the individual product page at www.routledge.com. It has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

Based on extended fieldwork conducted between 2007 and 2019, this book aims to answer a simple question: What is the meaning of home for people living in vernacular settlements in rural China? This question is particularly potent since rural China has experienced rapid and fundamental changes in the twenty-first century under the influences of national policies such as "Building a New Socialist Countryside" enacted in 2006 and "Rural Revitalization" announced in 2018. Drawing upon ethnographic fieldwork, building surveys, archival research, and over 600 photographs taken by residents along with their life stories, this book uncovers the meanings of home from rural residents’ perspectives, who belong to a social group that is underrepresented in scholarship and underserved in modern China. In other words, this study empowers rural residents by giving them voice. This book links the concepts of place, home, and tradition into an overarching argument: The meaning of home rests on the ideas of tradition, including identity, consanguinity, collectivity, social relations, land ownership, and rural lifestyle. The Introduction and Chapter 4 of this book is available for free in PDF format as Open Access from the individual product page at www.routledge.com. It has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

With China losing its previous competitive edge in manufacturing, industrial upgrading to the stage of innovation-driven development seems to be an imperative. Guangdong and its core region of Pearl River Delta are playing a role of pilot in finding a new development path for the whole country. Whether Guangdong can rebuild its global industrial competitiveness on innovation dynamics is significant to China's economic growth, both current and in the future. The book explores next-step strategies and policies for transforming Guangdong's industrial development to an innovation level, not only for reviewing its past experience or proving certain development models. A bigger part of the book is contributed to analyze the essential ways that Guangdong emerged as world factory, as well as the current problems encountered by business and government. This is because that the future can be only better prepared when the past and present, the strengths and weaknesses, are clearly identified and understood. The book tries to combine local knowledge and information with theoretical frameworks in the research on innovation management and policy to crystallize the nature of Guangdong's industrial development. The book presents an in-depth analysis of the rising and challenge of Guangdong as China's world factory. The book serves as an exploring trigger for those who are interested in the future of China's world factory.

Since the reform and opening-up in the late 1970s, Wenzhou City of China's Zhejiang Province has witnessed large-scale institutional change and rapid economic development. This book studies the institutional change and economic development in Wenzhou since China's reform and opening-up. It concludes that the most important characteristic of Wenzhou model is that the city is the first to promote industrialization and urbanization by privatization and marketization in Zhejiang. As privatization and marketization reflect reform, and industrialization and urbanization represent development, Wenzhou model promotes development through economic reform. In the early years of the reform and opening-up, the people of Wenzhou boldly faced the constraints of traditional planned economy, bravely explored the market-oriented reform and opened up a new path to regional economic development. This book also contains the stories of the people of Wenzhou.

This book systematically introduces magnetic flux leakage testing principles and their applications in practice. Signal detection, collection, processing, the inversion of magnetic flux leakage defect and 3D imaging are discussed in detail with extensive project experiences, making the book an essential reference for researchers, developers and engineers in nondestructive testing.

Computer networks need novel communication theory for transmitting data from sources to destinations within a predetermined restrict period of time according to a given quality of service (QoS). This book provides an analysis of min-plus algebra that is applied to network calculus in computer networks. The key contribution of this book is to discuss the analytical expressions of identity in min-plus algebra. Overall, this book can be used as a reference for researchers, engineers and postgraduates in the fields of communication networks, internet studies and cyber-physical networking systems in the aspect of applied functional analysis, in addition to min-plus algebra used in network calculus for computer scientists.