Jennifer Doudna

Nobelpriset i kemi 2020, för upptäckten av ett av genteknikens skarpaste verktyg: gensaxen CRISPR/Cas9." En vetenskaplig thriller och fängslande läsning" Venki Ramakrishnan, ordförande för The Royal Society och tidigare mottagare av Nobelpriset i kemiEn upptäckt med potential att rädda liv men också ödelägga dem. Inte sedan atomkraften har en ny teknologi haft så oöverskådliga konsekvenser att upphovsmännen känt sig tvungna att varna för sin upptäckt. I den här välskrivna vetenskapliga thrillern får vi följa Nobelprisvinnande Jennifer Doudna på jakt efter den stora upptäckten, en jakt som leder till svåra vägval och större makt än vi kunnat ana. Resultatet: gensaxen CRISPR, som gör det möjligt att redigera biologisk arvsmassa nästan lika enkelt som att klippa och klistra i en text. Tekniken kan komma att användas för att stoppa hiv, bota vissa cancersorter och förebygga genetiska sjukdomar. Men också för att tillföra nya, ärftliga egenskaper hos människan -- en möjlighet som leder till oerhörda etiska utmaningar. Den världsledande forskaren Jennifer Doudna, som tilldelades Nobelpriset i kemi 2020, berättar i Sprickan i skapelsen tillsammans med Samuel Sternberg om en av den moderna vetenskapens största upptäckter." Det finns en enorm kraft i gensaxen, som angår oss alla." Claes Gustafsson, ordförande i Nobelkommittén för kemi." Ett ovärderligt vittnesmål ... vi står i Doudnas skuld många gånger om" The Guardian"Obligatorisk läsning för varje engagerad medborgare" New York Review of Books"Sprickan i skapelsen, skriven av en av de främsta kvinnliga pionjärerna inom naturvetenskapen, är både olidligt spännande och skrämmande ... den här boken är en vägvisare till framtiden" Arianna Huffington"Framtiden är i våra händer som aldrig förr, och den här boken förklarar vad som står på spel som ingen annan" George Lucas

World-famous scientist Jennifer Doudna - winner of the 2020 Nobel Prize in Chemistry for creating the revolutionary gene-editing technique CRISPR - explains her discovery, describes its power to reshape the future of all life and warns of its use. 'AN INSTANT CLASSIC' Siddhartha Mukherjee A handful of discoveries have changed the course of human history. This book is about the most recent and potentially the most powerful and dangerous of them all. It is an invention that allows us to rewrite the genetic code that shapes and controls all living beings. As a result, dreams of genetic manipulation have become a stark reality: the power to cure disease and alleviate suffering, as well as to re-design any species, including humans, for our own ends. Jennifer Doudna is the co-inventor of this technology - known as CRISPR - and a scientist of worldwide renown. Writing with fellow researcher Samuel Sternberg, here she provides the definitive account of her discovery, explaining how this wondrous invention works and what it is capable of. She also asks us to consider what our new-found power means: how do we enjoy its unprecedented benefits while avoiding its equally unprecedented dangers?'The future is in our hands as never before, and this book explains the stakes like no other' George Lucas'One of the most PIONEERING women in science . . . Exhilarating' Arianna Huffington 'Thrilling' Adam Rutherford

Written and illustrated with unsurpassed clarity, "Molecular Biology: Principles and Practice" introduces fundamental concepts while exposing students to how science is done. The authors convey the sense of joy and excitement that comes from scientific discovery, highlighting the work of researchers who have shaped and who continue to shape the field today."

Written and illustrated with unsurpassed clarity, Molecular Biology: Principles and Practice introduces fundamental concepts while exposing students to how science is done. The authors convey the sense of joy and excitement that comes from scientific discovery, highlighting the work of researchers who have shaped - and who continue to shape - the field today. Key features include: Moment of Discovery Each chapter opens with a description of a significant breakthrough in molecular biology relevant to that chapter, as told by the scientist who made the discovery. They make this a relevant, living subject to students. Examples include: - Joe DeRisi, on his discovery of the SARS virus (Chapter 8) - Melissa Jurica, on her discovery of the first EM structures of spliceosomes (Chapter 16) - Bonnie Bassler, on her discovery of interspecies quorum sensing (Chapter 20) How We Know This end-of-chapter section combines fascinating stories of research and researchers with actual experimental data for students to analyze, often drawing on the work of the scientist featured in the chapter's 'Moment of Discovery.' This ensures the material covered in the book is always shown to be relevant to how scientists really work. Unanswered Questions A short section at the end of each chapter describes important areas still open to discovery, showing students that even well-covered subjects such as nucleic acid structure and DNA replication are far from fully explored. This emphasises the evolving nature of the subject and show students how their work could have impact in the future. Key Conventions These brief paragraphs clearly lay out for student some fundamental principles often glossed over by instructors and textbooks because they are so well understood by professionals. They are helpful to students, who could otherwise be thrown by such assumptions. Highlights Throughout each chapter, special features focus on fascinating topics that enhance student understanding of the concepts: * Medicine looks at diseases that arise from defects in biochemical pathways, or examples of how concepts learned in molecular biology have contributed to drug therapies or other treatments. * Technology focuses on cutting-edge molecular biology methods that students will likely be hearing about or even using in the future. * Evolution reveals the role of molecular biology research in understanding key biological processes and the connections between organisms. * A Closer Look highlights a wide variety of additional, intriguing topics. * Encourages practice and critical thinking End-of-Chapter Problems These give students the opportunity to think about and work with the chapter's key ideas. Each problem set concludes with a Data Analysis Problem, giving students the crucial experience of interpreting real data from actual research (most often the work described in the 'How We Know' section). Solutions to the problems can be found at the end of the book. (This title may not be available in all areas. Please contact your representative for more information.)