Michael Williams

Inspired by the work of Wilfrid Sellars, Michael Williams launches an all-out attack on what he calls "phenomenalism," the idea that our knowledge of the world rests on a perceptual or experiential foundation. The point of this wider-than-normal usage of the term "phenomenalism," according to which even some forms of direct realism deserve to be called phenomenalistic, is to call attention to important continuities of thought between theories often thought to be competitors. Williams's target is not phenomenalism in its classical sense-datum and reductionist form but empiricism generally. Williams examines and rejects the idea that, unless our beliefs are answerable to a "given" element in experience, objective knowledge will be impossible. Groundless Belief was first published in 1977. This second edition contains a new afterword in which Williams places his arguments in the context of some current discussions of coherentism versus the Myth of the Given and explains their relation to subsequent developments in his own epistemological views.

Peacekeeping in the late 1990s is a complex and diverse task, in which civilian and military personnel are working together to a greater degree than ever before. However, when an international body such as the UN takes strategic decisions, it does so with inadequate input from the military; in the field, there are clashes of culture, confusion over command and control arrangements and insufficient operational coordination. These issues also affect regional organisations such as NATO. The awkward management of operations and their uneven level of achievement have contributed to a decline in the number of UN peacekeeping operations since 1994. This paper argues that the balance between civilian and military expertise and advice at all levels of a peacekeeping mission - strategic, tactical and operational - needs to be reappraised. At the strategic level: * mandates must be clear, and must respond both to the needs of the situation and to the resources available * there must be regular dialogue between all the principal players, military and civilian; the military-staff capacity at UN headquarters should be made more effective, and should be responsible to the Security Council * major troop-contributing countries should be systematically involved in determining mandates, as well as in reviewing operational plans * senior military officers from all large troop-contributing countries should be based at a mission's field headquarters. At the operational level: * the office of the Special Representative of the Secretary-General - the head of a UN peacekeeping mission - should be strengthened. In non-UN operations, the authority of the High Representative needs to be increased * a cadre of civilian officials with peacekeeping experience needs to be developed; standard operating procedures for the civilian head of a mission to follow when dealing with the military need to be developed * greater emphasis should be placed on the 'softer' aspects of military science - managing resources, civilian control and human rights * the reluctance of civilians and non-governmental organisations to engage with the military should be addressed. Much experience has been gained from the peacekeeping operations of the 1990s, but both military and civilian participants must make considerably more progress before they can be said to have forged a partnership that makes them an effective intervention force

In Unnatural Doubts, Michael Williams constructs a masterly polemic against the very idea of epistemology, as traditionally conceived. Although philosophers have often found problems in efforts to study the nature and limits of human knowledge, Williams provides the first book that systematically argues against there being such a thing as knowledge of the external world. He maintains that knowledge of the world consitutes a theoretically coherent kind of knowledge, whose possibility needs to be defended, only given a deeply problematic doctrine he calls "epistemological realism." The only alternative to epistemological realism is a thoroughgoing contextualism.

When Europeans first reached the land that would become the United States they were staggered by the breadth and density of the forest they found. The existence of that forest, and the effort either to use or subdue it, have been constant themes in American history, literature, economics, and geography up to the meaning of the forest in American history and culture, he describes and analyzes the clearing and use of the forest from pre-European times to the present, and he traces the subsequent regrowth of the forest since the middle of the twentieth century. Dr Williams begins by exploring the role of the forest in American culture: the symbols, themes, and concepts - for example, pioneer woodsman, lumberjack, wilderness - generated by contact with the vast land of trees. He considers the Indian use of the forest, describing the ways in which native tribes altered it, primarily through fire, to promote a subsistence economy. Early European settlers, he shows, extracted many products from the forest, and also began the extensive clearance of trees that would continue for almost three hundred years. Succeeding chapters, organized by topic and region, cover agricultural and industrial effects upon and uses of the forest. Dr Williams explores the rise (and often fall) of industries based upon forest products: naval stores, timber for building, charcoal and the iron industry, the railroads. Attention is devoted to the forests of the Middle West, the South, and the Pacific Northwest. By the late nineteenth century Americans began to realize that the forest was not boundless and moved to preserve those portions, still extensive, that remained. In the wake of the movement for preservation, Dr Williams describes how the forest began to regrow, especially after 1950, in areas where it had originally been vigorous and healthy, a development that continues today.

Historically, the major emphasis on the study of purinergic systems has been predominantly in the areas of physiology and gross pharmacology. The last decade has seen an exponential in- crease in the number of publications related to the role of both adenosine and A TP in mammalian tissue function, a level of interest that has evolved from a more molecular focus on the identity of adenosine and A TP receptor subtypes and the search for selective ligands and development of radioligand binding assays by Fred Bruns and colleagues (especially that for A receptors) that played z a highly significant role in advancing research in the area. In the 60 years since adenosine was first shown to be a potent hypotensive agent, a considerable investment has been made by several pharmaceutical companies-including Abbott, Byk Gulden, Takeda, Warner-LambertlParke Davis, Boehringer Mann- heim, Boehringer Ingelheim, Nelson/Whitby Research and CffiA- Geigy-as well as John Daly's laboratory at the National Institutes of Health, to design new adenosine receptor ligands, and both agon- ists and antagonists with the aim of developing new therapeutic entiities. Numerous research tools have derived from these efforts including: 2-chloroadenosine, R-PIA (~-phenylisopropyladeno- sine; NECA (5' N-ethylcarboxamidoadenosine); CV1808; CI936; PD 125,944; ~-benzyladenosine; PACPX; CPX; CPT; XAC; CGS 15943 and CGS 21680. Yet in the realm of therapeutics it was only in 1989 that adenosine itself was approved for human use in the treatment of supraventricular arrythmias.

Twice in this century popular revolts against colonial rule have occured in the Banten district of West Java. These revolts, conducted largely under an Islamic leadership, also proclaimed themselves Communist. Islamic Communism is seemingly a paradox. This is especially the case when one considers that probably no religion has proved more resistant to Communist ideology than Islam. Michael Williams here details the complicated history of the Bantenese revolts in the twentieth century and probes the ideological riddle of Islamic Communism. Modern history is replete with examples of regions with a long history of organizing themselves politically to resist intrusion on their territory, resources, and people. This book establishes that in Indonesia, the Bantenese were among the most practiced exponents of resistance.

The conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar- maceutical company or a breakthrough at the research level that has agreed applicability in response to a valid therapeutic demand. Although the intelligent design and development of new thera- peutic entities, as evidenced by Sir James Black's H -receptor an- 2 tagonist cimetidine (Tagamet), is intellectually satisfying, many novel drugs arise from serendipity, from the chance observation of the research scientist or the clinician, that a compound has unex- pected actions of use for the treatment of human disease states. Drugs that have been identified by this route include the antipsy- chotic chlorpromazine and the putative anxiolytic buspirone. The events surrounding the process of drug discovery and de- velopment are the theme of the present volume, which attempts to present, in a logical and lucid manner, the complexity of a process that is often naively assumed to represent nothing more than the identification of a new compound and its rapid introduction into humans, free of such complications as efficacy, selectivity, safety, bioavailability, toxicity, and need.

This is a detailed study of how the Somerset Levels, originally a large tract of marsh, were drained and reclaimed to becomes one of the most agriculturally productive areas of south-west England. The story of the draining of this region brings to light significant comparisons and contrasts with other reclaimed lowlands and extends our knowledge of one of the processes by which the British landscape has changed. This is an important book, which brings together information on an area that has until now received very little attention; it also shows just how early massive reclamation began. It will be of interest to both geographers and historians.