Morten L. Kringelbach

This is an open access title available under the terms of a CC BY-NC-ND 4.0 licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Whole Brain Modelling: Cartography of the Dynamics of Mind provides a rigorous yet accessible examination of advanced whole-brain computational models that reveal the mechanisms driving brain dynamics—critical for mapping the mind’s complex architecture. Designed for students and researchers in neuroscience, psychology, biology, physics, mathematics, engineering, and medical science, it bridges disciplines while making sophisticated mathematical and physical principles approachable. Through the integration of cutting-edge neuroimaging and computational modeling, the text demonstrates how in silico brain simulations can replicate human neural activity with high fidelity. These models serve as experimental platforms, enabling virtual lesioning and stimulation to uncover causal mechanisms of brain function. Readers will explore how hierarchical coordination of brain dynamics shapes cognition and consciousness, informed by frameworks from modern physics such as stochastic thermodynamics and turbulence. These concepts are transforming our understanding of neural processes in both health and disease. By combining empirical imaging with state-of-the-art causal modeling, this book lays the foundation for a new paradigm in brain science—one that not only explains neural processing but also opens pathways to innovative interventions, improved treatments, and ultimately, enhanced well-being.

Emotions are often seen as an intrinsic part of what makes us human; they underpin how we feel about ourselves, and our interactions with others. New discoveries continue to reveal more about how emotion translates into brain activity - what is actually happening in our brains to make us 'feel' the way we do. They are also illuminating our understanding of dysfunctional emotions - the emotional basis of addiction, or the maladaptive emotional behaviors that characterize our difficult, and sometimes pathological, relationship with food. Emotion presents the fundamental principles of the neural mechanisms underlying emotional processing as well as reviewing our current scientific understanding of pleasure and emotion. The book takes the reader from everyday conceptions of pleasure and emotion through to the latest insights into the nature and functions of emotions at the interface of psychology and neuroscience, before exploring topics such as the nature of subjective experience and future possibilities including emotions in silico. Throughout, the book focuses on the principles of reward systems in the brain and its links with mainstream psychology, helping the reader to understand the function and nature of emotion and pleasure, and its relevance to the rest of psychology. In addition, it also offers a clear understanding of fundamental topics such as the social emotions, individual emotions and the role of emotion and pleasure in decision making. The book also encourages the reader to achieve a better understanding of emotional disorders, which are central to clinical psychology and the treatment of a range of psychiatric disorders. Emotion is the ideal guide for any student wanting a clear, contemporary introduction to this complex yet fascinating subject. Online Resource Centre For registered adopters of the book: - Figures from the book in electronic format - A series of Journal Clubs - suggested papers and discussion questions related to topics featured in the book

Pleasure is fundamental to well-being and the quality of life, but until recently, was barely explored by science. Current research on pleasure has brought about ground-breaking developments on several fronts, and new data on pleasure and the brain have begun to converge from many disparate fields. The time is ripe to present these important findings in a single volume, and so Morten Kringelbach and Kent Berridge have brought together the leading researchers to provides a comprehensive review of our current scientific understanding of pleasure. The authors present their latest neuroscientific research into pleasure, describing studies on the brain's role in pleasure and reward in animals and humans, including brain mechanisms, neuroimaging data, and psychological analyses, as well as how their findings have been applied to clinical problems, such as depression and other disorders of hedonic well-being. To clarify the differences between their views, the researchers also provide short answers to a set of fundamental questions about pleasure and its relation to the brain. This book is intended to serve as both a starting point for readers new to the field, and as a reference for more experienced graduate students and scientists from fields such as neuroscience, psychology, psychiatry, neurology, and neurosurgery.

Many people believe that pleasure and desire are obstacles to reasonable and intelligent behavior. In The Pleasure Center, Morten Kringelbach reveals that what we desire, what pleases us--in fact, our most base, animalistic tendencies--are actually very important sources of information. They motivate us for a good reason. And understanding that reason, taking that reason into account, and harnessing and directing that reason, can make us much more rational and effective people. In exploring the many facets of pleasure, desire and emotion, Kringelbach takes us through the whole spectrum of human experience, such as how emotion fuels our interest in things, allowing us to pay attention and learn. He investigates the reward systems of the brain and sheds light on some of the most interesting new discoveries about pleasure and desire. Kringelbach concludes that if we understand and accept how pleasure and desire arise in the complex interaction between the brain's activity and our own experiences, we can discover what helps us enjoy life, enabling us to make better decisions and, ultimately, lead happier lives.