Ralf Huss

Die Nanotechnologie ist neben der Künstlichen Intelligenz eine der Zukunftstechnologien in der Medizin und der Gesundheitsversorgung, die völlig neue Behandlungs- und Diagnosemöglichkeiten in den kleinsten Winkeln unseres Körpers möglich machen wird: - Detailliertere Diagnosen in einem Nanomaßstab - Einsichten in biomedizinische Prozesse in Echtzeit - Bedarfsgerechte Dosierung von Therapien vor Ort und bei Bedarf - Reduzierte Nebenwirkungen und nachhaltige Wirkungen. In 9 anschaulich und einprägsam geschriebenen Kapiteln gibt der Autor zahlreiche Beispiele einer angewandten Nanotechnologie in der Medizin und der Gesundheitsforschung, einschließlich einer Beschreibung von möglichen Chancen und Risiken jetzt und in der vorhersehbaren Zukunft. Keine andere Disziplin vereint Expertenwissen aus der Physik, Biologie, Chemie, den Ingenieurwissenschaften und der Medizin so sehr miteinander wie die Nanomedizin. Sie ist dadurch ein sich rasant entwickelnder, aber auch komplexer Bereich sowohl für eine noch präzisere Diagnostik als auch für sehr gezielte Behandlung besonders von schwerwiegenden Erkrankungen und chronischen Krankheitszuständen.

This book provides an introduction into the field of digital medicine, its wide spectrum of current clinical applications, and the future practice of medicine. With "digital health" and "digital medicine" at its core, it focuses on the combination of therapeutics with modern hard- and software solutions, including artificial intelligence and advanced diagnostic technologies such as augmented imaging and ingestible or wearable (nano)sensors, to provide best patient care. In the four parts of this book, experts in the field have authored use cases and guiding principles on the visualization of patient data analytics and clinical decision support tools, including robotic-guided interventions, as well as nursing research along with palliative and inpatient care. The book also provides examples of "digital medicine" from almost all clinical disciplines together with technical and e-learning solutions.

This book describes the changing role of pathology in aiding reproducible and accurate patient selection for predictive cancer therapy. Particular attention is given to the clinical application of cutting-edge cancer biomarkers to accurately select patients for targeted cancer therapy and how artificial intelligence can improve the precision of treatments. The advent and basis of predictive cancer care, the role of pathologists in translational cancer research, the analysis of cancer samples, the management of biopsy results, and the accuracy of biopsy results are also discussed. Precision Cancer Medicine: Role of the Pathologist details how pathologists can use the latest biomarkers and apply artificial intelligence technology in cancer diagnosis and management. It is also relevant to oncologists and medical practitioners involved in cancer management seeking an up-to-date resource on the topic.

This book describes the changing role of pathology in aiding reproducible and accurate patient selection for predictive cancer therapy. Particular attention is given to the clinical application of cutting-edge cancer biomarkers to accurately select patients for targeted cancer therapy and how artificial intelligence can improve the precision of treatments. The advent and basis of predictive cancer care, the role of pathologists in translational cancer research, the analysis of cancer samples, the management of biopsy results, and the accuracy of biopsy results are also discussed. Precision Cancer Medicine: Role of the Pathologist details how pathologists can use the latest biomarkers and apply artificial intelligence technology in cancer diagnosis and management. It is also relevant to oncologists and medical practitioners involved in cancer management seeking an up-to-date resource on the topic.

Die Informationstechnologien haben, wie in alle Lebensbereiche, längst auch Einzug in Medizin und Gesundheitsversorgung gehalten:- digitale Systeme erstellen Diagnosen, errechnen Krankheitsrisiken und geben individuelle Therapieempfehlungen,- neue Technologien eröffnen ungeahnte Behandlungsmöglichkeiten,- aus der Analyse großer Datenmengen ergeben sich ein tieferes Verständnis der Entstehung und der Verläufe von Krankheiten und neue Therapieideen. In diesem Spannungsfeld verändern sich auch die Erwartungen, die Patient und Arzt aneinander stellen, und ihr jeweiliges Rollenverständnis. In sieben anschaulich und einprägsam geschriebenen Kapiteln stellt der Autor die Hauptfelder der Digitalisierung in der Medizin dar, sowohl die Chancen, die sie für viele Patienten beinhalten, als auch die Gefahren, die sie für die Bewahrung der Privatsphäre und die am Patienten orientierte ärztliche Behandlung mit sich bringen können – eine gut lesbare Einführung für alle, die sich für die Entwicklung der Medizin und des Gesundheitswesens interessieren.

In the age of digitization our society is transformed into a new state. In particular, machine intelligence dramatically elevates our capability to create and digest information. Naturally, healthcare is also impacted by this trend and will even be more transformed into a informatic driven discipline in the future. In the most important area of histo-pathology, the interpretation of tissue slices from cancer patients, informatics will have an early and huge impact on treatment decisions and probably will act as the leading discipline for this transformation in medicine. Tissue Phenomics provides a comprehensive methodology aiming at the discovery of the most accurate tissue-based decision support algorithm by close integration of assay development, image analysis and bioinformatics, and optimization feedback loops. In this book the methodology of Tissue Phenomics and its benefits and wealth’s are described. The different components of Tissue Phenomics are explained in the different chapters. In the chapters 2 to 4 of this book different authors describe various approaches on how to convert the wealth of tissue slide pixel data into mineable information using knowledge-based and data-driven image analysis methods. Subsequently, the datafication of images and the bioinformatics part plays a crucial role in generating prognostic and predictive models for disease progression. The integration of other data sources such as genomics, radiomics and patient related information is also important and is described as well. As discussed in chapters 5 and 6, these models may classify patients in distinct groups such as those responding to a given therapy. Since Tissue Phenomics provides a huge set of potentially prognostic features (phenes), one focus of both chapters is robust feature selection methods by advanced Monte-Carlo cross validation algorithms. In chapter 7 we discuss multiple application examples of Tissue Phenomics in academic and commercial settings and its tremendous impact to advances in biomedical sciences. Building on the successes in research, chapters 8 and 9 discuss applications in clinical environments and provide a flavor to the future envision in chapter 10, where tissue datafication and subsequent patient profiling is part of every routine examination, with the goal to best match patients with the most successful therapy, as predicted by tissue phenes.

This textbook is a comprehensive overview of the development of cell-based biopharmaceuticals. Beginning with the underlying biology of stem cell and cell-based products, it traces the long and complex journey from preclinical concept to initiation of a pivotal clinical trial and the potential business model behind it. The book also takes into consideration the different regulatory landscapes and their continuous evolution in Europe, North America and other parts of the world. The authors describe a path to manufacture a clinical grade therapeutic that passes all necessary quality measures as a robust and marketable product including an outlook on next generation products and innovative strategies. This reference book is a must-have guide for any professional already active in biopharmaceuticals and anyone interested in getting involved in a scientific, medical or business capacity.