Ramana Hechhu

Sublingual drug delivery traditionally" involves systemic administration via mucosal membrane of floor of mouth or the ventral surface of tongue. The sublingual mucosa is relatively permeable due to the lipoidal nature of mucous membrane with a rich vasculature, which allows rapid absorption and has acceptable bioavailability. It is convenient, facilitates ease of administration and its ability to bypass hepatic first pass. This research elaborate about development Sublingual" tablets of ISBD NT(Isosorbide dinitrate). Compared to all "formulations ISDN4 showed high" % "drug release i.e., 97.15 % "in 8 min so it is considered as best formulation which contains Pullulan as super disintegrate in the concentration of 10 mg".

High performance liquid chromatography is at present one of the most sophisticated tool of the analysis. The estimation of Thiocolchicoside and Lornoxicam was done by RP-HPLC. The Phosphate buffer was pH 3.0 and the mobile phase was optimized with consists of Methanol: Phosphate buffer mixed in the ratio of 70:30 % v/ v. Inertsil C18 column C18 (4.6 x 150mm, 5μm) or equivalent chemically bonded to porous silica particles was used as stationary phase. The detection was carried out using UV detector at 260 nm. The solutions were chromatographed at a constant flow rate of 0.8 ml/min. the linearity range of Thiocolchicoside and Lornoxicam were found to be from 100-500 μg/ml of Thiocolchicoside and 1-5μg/ml of Lornoxicam . Linear regression coefficient was not more than 0.999. The values of % RSD are less than 2% indicating accuracy and precision of the method. The percentage recovery varies from 98-102% of Thiocolchicoside and Lornoxicam . LOD and LOQ were found to be within limit. The results obtained on the validation parameters met ICH and USP requirements .it inferred the method found to be simple, accurate, precise and linear. The method was found to be having suitable application.

Since the last decade, the paradigm has been shifted to "Green Chemistry" to meet the challenges of sustainable development. It has become the quest and challenge for chemists to develop green reaction process without affecting their efficiency to reduce the environmental impact. Further, it is likely that the green chemistry trend will continue to grow over the next few decades. Interestingly, the Biginelli-scaffolds have shown promising value in drug development as they exhibit a wide spectrum of pharmacological activities. During the past years, copious research has been done on Biginelli-scaffolds and several reaction conditions were reported to ease the classical Biginelli-reaction. This book provides insights on green method for the synthesis of Biginelli-scaffolds by both microwave and conventional methods using sulfamicacid as a potential catalyst and further synthesis of 4-aryl-3,4-dihyropyrimidin-2(3H)-onesand biological screening for various pharmacological activities.